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Hormone-replacement...
Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis : a cohort study
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- Hall, Per (författare)
- Karolinska Institutet
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- Ploner, Alexander (författare)
- Karolinska Institutet
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- Bjohle, Judith (författare)
- Karolinska Institutet
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Huang, Fei (författare)
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Lin, Chin-Yo (författare)
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Liu, Edison T (författare)
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Miller, Lance D (författare)
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- Nordgren, Hans (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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- Pawitan, Yudi (författare)
- Karolinska Institutet
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Shaw, Peter (författare)
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- Skoog, Lambert (författare)
- Karolinska Institutet
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- Smeds, Johanna (författare)
- Karolinska Institutet
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- Wedren, Sara (författare)
- Karolinska Institutet
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Ohd, John (författare)
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- Bergh, Jonas (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2006-06-30
- 2006
- Engelska.
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Ingår i: BMC Medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 4, s. 16-
- Relaterad länk:
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http://www.ncbi.nlm....
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https://bmcmedicine....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Postmenopausal hormone-replacement therapy (HRT) increases breast-cancer risk. The influence of HRT on the biology of the primary tumor, however, is not well understood. Methods: We obtained breast-cancer gene expression profiles using Affymetrix human genome U133A arrays. We examined the relationship between HRT-regulated gene profiles, tumor characteristics, and recurrence-free survival in 72 postmenopausal women. Results: HRT use in patients with estrogen receptor ( ER) protein positive tumors (n = 72) was associated with an altered regulation of 276 genes. Expression profiles based on these genes clustered ER-positive tumors into two molecular subclasses, one of which was associated with HRT use and had significantly better recurrence free survival despite lower ER levels. A comparison with external data suggested that gene regulation in tumors associated with HRT was negatively correlated with gene regulation induced by short-term estrogen exposure, but positively correlated with the effect of tamoxifen. Conclusion: Our findings suggest that post-menopausal HRT use is associated with a distinct gene expression profile related to better recurrence-free survival and lower ER protein levels. Tentatively, HRT-associated gene expression in tumors resembles the effect of tamoxifen exposure on MCF-7 cells.
Nyckelord
- Breast Neoplasms/classification/diagnosis/*genetics/mortality/pathology
- Cell Line; Tumor
- Cohort Studies
- DNA Primers
- Disease-Free Survival
- Estrogen Replacement Therapy
- Female
- Gene Expression Profiling
- Humans
- Postmenopause
- Premenopause
- Receptors; Estrogen/*analysis
- Receptors; Progesterone/*analysis
- Survival Analysis
- Transcription; Genetic
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hall, Per
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Ploner, Alexande ...
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Bjohle, Judith
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Huang, Fei
-
Lin, Chin-Yo
-
Liu, Edison T
-
visa fler...
-
Miller, Lance D
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Nordgren, Hans
-
Pawitan, Yudi
-
Shaw, Peter
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Skoog, Lambert
-
Smeds, Johanna
-
Wedren, Sara
-
Ohd, John
-
Bergh, Jonas
-
visa färre...
- Artiklar i publikationen
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BMC Medicine
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet