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Self-sampling of th...
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Sanner, KarinUppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson
(författare)
Self-sampling of the vaginal fluid at home combined with high-risk HPV testing
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-08-04
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Springer Science and Business Media LLC,2009
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-111819
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-111819URI
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https://doi.org/10.1038/sj.bjc.6605194DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: Around 65% of women with cervical carcinoma in Sweden have not attended an organised screening. We therefore investigated the value of using self-sampling at home in combination with a test for high-risk human papilloma virus (HPV) to increase participation. METHODS: A total of 2829 women 30-58 years old, who had not attended the organised screening for > or = 6 years, were recruited. They were offered self-sampling at home (Qvintip) and recommended to send the collected vaginal fluid to a laboratory for analysis of the presence of high-risk HPV (Hybrid Capture 2 method). RESULTS: A total of 39.1% of the women accepted home sampling. These women disclosed a relatively high prevalence of high-risk HPV, which decreased with age, from 11.1% in women 30-39 years old to 2.9% in women > or =50 years . Follow-up disclosed histological cervical intraepithelial neoplasm (CIN) 2-3 lesions in 43.2% of the women with a persistent HPV infection, corresponding to 2.0% of the total number of participating women. The sensitivity of a single smear to detect the histological CIN 2-3 lesions were only 52.6%, even if all abnormal smears (atypical squamous cells of unknown significance (ASCUS)-CIN 3)) were included. CONCLUSION: The use of self-sampling at home in combination with testing for high-risk HPV increases the participation rate of the organised screening and detects almost twice as many women with pre-malignant cell alterations (CIN 2-3) in comparison those with a single cytological smear.
Ämnesord och genrebeteckningar
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cervix
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cytology
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screening
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HPV test
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self-sampling
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wikström, IngridUppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson(Swepub:uu)ingrwiks
(författare)
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Strand, A.Uppsala universitet,Dermatologi och venereologi
(författare)
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Lindell, MonicaUppsala universitet,Institutionen för genetik och patologi
(författare)
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Wilander, ErikUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)erikwila
(författare)
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Uppsala universitetInstitutionen för kvinnors och barns hälsa
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Cancer: Springer Science and Business Media LLC101:5, s. 871-8740007-09201532-1827
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