GeneFinder: "in silico" positional cloning of trait genes

Martinez Barrio, Alvaro,1977-Uppsala universitet,Centrum för bioinformatik,Bongcam-Rudloff (författare)

Motivation: Positional cloning of trait genes is extremely laborious and the amount of information available on gene function in different organisms is increasing so rapidly that it is hard for a research group to collect all the relevant information from a number of data sources without performing a large number of manual and time consuming searches. Results: A web service application named GeneFinder was designed and implemented. It collects selected available information related to trait loci within a given chromosomal region that control a specific phenotype. The information contains details on gene function, disease conditions, tissue expression as well as predicted gene homologies in several other species. The information gathered is further ordered by a special-purpose ranking algorithm. A web interface to the GeneFinder web service was also developed where the results are presented in a ranked list easing its interpretation. We explain the design of the architecture, show how our web interface works, and finally test a candidate region. Availability: GeneFinder is publicly available and free to use. The web interface is available at http://www.genefinder.org/.

Feifei, XuUppsala universitet,Institutionen för evolution, genomik och systematik,Molekylär evolution (författare)
Lagercrantz, ErikDepartment of Animal Breeding and Genetics, Swedish University of Agricultural Sciences,Bongcam-Rudloff (författare)
Bongcam-Rudloff, ErikDepartment of Animal Breeding and Genetics, Swedish University of Agricultural Sciences,Bongcam-Rudloff (författare)
Uppsala universitetCentrum för bioinformatik (creator_code:org_t)

Av författaren/redakt...: Martinez Barrio, ...; Feifei, Xu; Lagercrantz, Eri ...; Bongcam-Rudloff, ...

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