Unique expression of connexins in the human cochlea

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Boström Anders) > (2005-2009) > Unique expression o...

Details
MARC

Liu, WeiUppsala universitet,Öron-, näs- och halssjukdomar (author)

Unique expression of connexins in the human cochlea

Article/chapterEnglish2009

Publisher, publication year, extent ...

Elsevier BV,2009
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-113209
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113209URI
https://doi.org/10.1016/j.heares.2009.01.010DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Mutations in the genes GJB2 and GJB6, which encode the proteins Connexin 26 (Cx26) and Connexin 30 (Cx30), have been linked to nonsyndromic prelingual deafness in humans. These proteins may form so-called gap junctions (GJ) or transcellular pathways between cells. The pathogenesis of deafness due to GJ Connexin mutations remains unclear partly because examinations performed in the human ear are infrequent. Here we analysed the expression and distribution of Cx26 and Cx30 in five fresh normal human cochleae taken out at occasional surgery. Immunohistochemistry including confocal microscopy in decalcified specimen showed that these proteins are widely expressed in the human cochlea. In the lateral wall there was strong antibody co-labeling for Cx26 and Cx30 that support the existence of channels comprising heteromeric Cx26/Cx30 connexons. In the organ of Corti there were some co-labeling in the supporting cell area including mainly the Claudius cells and Deiter cells of these two Cxs, apart from isolated Cx26 and Cx30 labeling in the same area, suggestive of both homomeric/homotypic pattern and hybrid pattern (heteromeric or heterotypic). Cx30, Cx26 and Connexin 36 (Cx36) immunoreactivity was also associated with spiral ganglion type I neurons, the latter being a gap junction protein specific to neurons. Gap-junction-based electrical synapses are not known to occur in mammalian auditory system other than in bats where they may play a role for fast electrical nerve transmission useful for echolocation. Their potential role in the processing of human auditory nerve signaling as well as non-GJ roles of the connexins in human cochlea is discussed.

Subject headings and genre

MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Boström, MarjaUppsala universitet,Plastikkirurgi(Swepub:uu)marjbost (author)
Kinnefors, AndersUppsala universitet,Öron-, näs- och halssjukdomar(Swepub:uu)ankin677 (author)
Rask-Andersen, HelgeUppsala universitet,Öron-, näs- och halssjukdomar(Swepub:uu)helgraan (author)
Uppsala universitetÖron-, näs- och halssjukdomar (creator_code:org_t)

Related titles

In:Hearing Research: Elsevier BV250:1-2, s. 55-620378-59551878-5891

Internet link

Find in a library

Hearing Research (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Liu, Wei; Boström, Marja; Kinnefors, Ander ...; Rask-Andersen, H ...

Articles in the publication: Hearing Research

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se