Differences in endpoints between the Swedish W-E (two county) trial of mammographic screening and the Swedish overview: methodological consequences

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Holmberg, LarsUppsala universitet,Endokrinkirurgi,Kings College London (author)

Differences in endpoints between the Swedish W-E (two county) trial of mammographic screening and the Swedish overview : methodological consequences

Article/chapterEnglish2009

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2009-06-29
SAGE Publications,2009
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LIBRIS-ID:oai:DiVA.org:uu-113864
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113864URI
https://doi.org/10.1258/jms.2009.008103DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25328URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:119162773URI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19896URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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OBJECTIVES: To characterize and quantify the differences in the number of cases and breast cancer deaths in the Swedish W-E Trial compared with the Swedish Overview Committee (OVC) summaries and to study methodological issues related to trials in secondary prevention. SETTING: The study population of the W-E Trial of mammography screening was included in the first (W and E county) and the second (E-county) OVC summary of all Swedish randomized mammography screening trials. The OVC and the W-E Trial used different criteria for case definition and causes of death determination. METHOD: A Review Committee compared the original data files from W and E county and the first and second OVC. The reason for a discrepancy was determined individually for all non-concordant cases or breast cancer deaths. RESULTS: Of the 2615 cases included by the W-E Trial or the OVC, there were 478 (18%) disagreements. Of the disagreements 82% were due to inclusion/exclusion criteria, and 18% to disagreement with respect to cause of death or vital status at ascertainment. For E-County, the OVC inclusion rules and register based determination of cause of death (second OVC) rather than individual case review (W-E Trial and 1st OVC) resulted in a reduction of the estimate of the effect of screening, but for W-County the difference between the original trial and the OVC was modest. CONCLUSIONS: The conclusion that invitation to mammography screening reduces breast cancer mortality remains robust. Disagreements were mainly due to study design issues, while disagreements about cause of death were a minority. When secondary research does not adhere to the protocols of the primary research projects, the consequences of such design differences should be investigated and reported. Register linkage of trials can add follow-up information. The precision of trials with modest size is enhanced by individual monitoring of case status and outcome status such as determination of cause of death.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Duffy, S. W.Wolfson Institute for Preventative Medicine (author)
Yen, A. M.Wolfson Institute for Preventative Medicine (author)
Tabár, L.Uppsala University (author)
Vitak, B.Östergötlands Läns Landsting,Linköpings universitet,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping (author)
Nyström, LennarthUmeå universitet,Epidemiologi och folkhälsovetenskap,Umea University(Swepub:umu)leny0002 (author)
Frisell, J.Karolinska Institutet,Karolinska Institute (author)
Uppsala universitetEndokrinkirurgi (creator_code:org_t)

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In:Journal of Medical Screening: SAGE Publications16:2, s. 73-800969-14131475-5793

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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