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  • Ahlin, CeciliaÖrebro universitet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi (author)

Cyclin A is a proliferative marker with good prognostic value in node-negative breast cancer

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-113865
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113865URI
  • https://doi.org/10.1158/1055-9965.EPI-09-0169DOI
  • https://lup.lub.lu.se/record/1469351URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119330250URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-19185URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Proliferative markers are not recommended as prognostic   factors for clinical use in breast cancer due to lack of   standardization in methodology. However, proliferation is driving   several gene expression signatures emphasizing the need for a reliable   proliferative marker IF or clinical use. Studies suggest that cyclin A   is a prognostic marker with satisfying reproducibility. We investigated   cyclin A as a prognostic marker in node-negative breast cancer using   previously defined cutoff values.   Patients and Methods: In a case-control study, we defined 190 women who   died from breast cancer as cases and 190 women alive at the time for   the corresponding case's death as controls. Inclusion criteria were   tumor size <= 50 mm, no lymph node metastases and no adjuvant   chemotherapy. Tumor tissues were immunostained for cyclin A using   commercially available antibodies.   Results: We found a statistically significant association between   expression of cyclin A and breast cancer death in a univariate model:   odds ratio for cyclin A(ave) 2.7 [95% confidence interval (CI),   1.7-4.3] and cyclin A(max) 3.4 (CI, 2.1-5.5). Corresponding odds ratio   for Ki67 were Ki67(ave) 1.9 (CI, 1.2-3.1) and Ki67(max) 1.7 (CI,   1.1-2.7) and for grade 3.1 (CI, 1.8-5.1). Cyclin A was strongly   correlated to Ki67 and grade why a model including all was not   appropriate.   Conclusions: Cyclin A is a prognostic factor for breast cancer death in   node-negative patients using standardized methodology regarding scoring   and cutoff values. Adding cyclin A as a proliferative marker to established clinicopathologic factors will improve the separation of  low and high risk breast cancer.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Zhou, WenjingUppsala universitet,Endokrinkirurgi(Swepub:uu)wenzh820 (author)
  • Holmqvist, Marit (author)
  • Holmberg, LarsUppsala universitet,Endokrinkirurgi(Swepub:oru)lshg (author)
  • Nilsson, CeciliaLund University,Lunds universitet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Centrum för klinisk forskning, Västerås,Enheten för pediatrisk hematologi,Forskargrupper vid Lunds universitet,Paediatric Hematologic Research Group,Lund University Research Groups(Swepub:lu)pedi-cni (author)
  • Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-kji (author)
  • Blomqvist, CarlUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi(Swepub:uu)carlblom (author)
  • Amini, Rose-MarieKarolinska Institutet,Uppsala universitet,Institutionen för genetik och patologi(Swepub:uu)roseamin (author)
  • Fjällskog, Marie-LouiseUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi(Swepub:uu)marifjal (author)
  • Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi (creator_code:org_t)

Related titles

  • In:Cancer Epidemiology, Biomarkers and Prevention18:9, s. 2501-25061055-99651538-7755

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