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  • Johansson, H.-E.Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics (author)

Gastric bypass alters the dynamics and metabolic effects of insulin and proinsulin secretion

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007-09-26
  • Wiley,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-11731
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-11731URI
  • https://doi.org/10.1111/j.1464-5491.2007.02240.xDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aims Hyperproinsulinaemia is associated with obesity and is a risk factor for Type 2 diabetes. We explored the dynamics of proinsulin and insulin and postprandial effects on glucose and lipids in subjects who had undergone gastric bypass (GBP) surgery compared with morbidly obese (MO) subjects and normal weight control subjects (NW). Methods Subjects free from diabetes were recruited: 10 previously MO subjects [body mass index (BMI) ± SD, 34.8 ± 6.2 kg/m2] who had undergone GBP surgery, 10 MO subjects (BMI 44 ± 3.1 kg/m2) and 12 NW control subjects (BMI 23.2 ± 2.4 kg/m2). After an overnight fast, a standard meal (2400 kJ) was ingested and glucose, proinsulin, insulin free fatty acids and triglycerides were determined up to 180 min. Results Fasting proinsulin was similar in the GBP group and NW control subjects, but threefold increased in MO subjects (P < 0.05). Postprandial AUC for glucose was similar in the three groups and AUC for proinsulin was high in MO, intermediate in the GBP group and lowest in NW control subjects (P for trend = 0.020). Postprandial proinsulin at 60 min was similar in the GBP group and MO subjects and twofold higher than in NW control subjects. Postprandial proinsulin at 180 min was normal in the GBP group, but fivefold increased in MO subjects (P = 0.008). Insulin increased rapidly at 30 min in the GBP group and was normal at 90 min, whereas insulin was still increased at 90-180 min in the MO subjects (P < 0.001). Conclusions MO subjects, free from diabetes, have elevated proinsulin concentrations in the fasting as well as the postprandial phase. After GBP surgery markedly lower fasting and postprandial proinsulin concentrations were observed, although BMI was higher compared with NW control subjects.

Subject headings and genre

  • Gastric by-pass
  • Insulin
  • Obesity
  • Proinsulin
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Öhrvall, MargaretaUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics(Swepub:uu)margohrv (author)
  • Haenni, ArvoUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics (author)
  • Sundbom, MagnusUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)magsundb (author)
  • Edén Engström, BrittUppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism(Swepub:uu)brittee (author)
  • Karlsson, F. AndersUppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism(Swepub:uu)anderska (author)
  • Zethelius, BjörnUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics(Swepub:uu)bjorzeth (author)
  • Uppsala universitetInstitutionen för folkhälso- och vårdvetenskap (creator_code:org_t)

Related titles

  • In:Diabetic Medicine: Wiley24:11, s. 1213-12200742-30711464-5491

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