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Incidence of chroni...
Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm
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de Marco, Roberto (author)
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Accordini, Simone (author)
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Cerveri, Isa (author)
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Corsico, Angelo (author)
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Antó, Josep M. (author)
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Künzli, Nino (author)
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- Janson, Christer (author)
- Uppsala universitet,Lungmedicin och allergologi
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Sunyer, Jordi (author)
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Jarvis, Deborah (author)
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Chinn, Susan (author)
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Vermeire, Paul (author)
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Svanes, Cecilie (author)
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Ackermann-Liebrich, Ursula (author)
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Gislason, Thorarinn (author)
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Heinrich, Joachim (author)
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Leynaert, B. (author)
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Neukirch, F. (author)
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Schouten, Jan P. (author)
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Wjst, Matthias (author)
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Burney, Peter (author)
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: American Journal of Respiratory and Critical Care Medicine. - 1073-449X .- 1535-4970. ; 175:1, s. 32-39
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Rationale: The few prospective studies aimed at assessing the incidence of chronic obstructive pulmonary disease (COPD) in relation to the presence of chronic cough/phlegm have produced contrasting results. Objectives: To assess the incidence of COPD in a cohort of young adults and to test whether chronic cough/phlegm and dyspnea are independent predictors of COPD. Methods: An international cohort of 5,002 subjects without asthma (ages 20-44 yr) with normal lung function (FEV1/FVC ratio ≥ 70%) from 12 countries was followed from 1991-2002 in the frame of the European Community Respiratory Health Survey II. Incident cases of COPD were those who had an FEV 1/FVC ratio less than 70% at the end of the follow-up, but did not report having had a doctor diagnose asthma during the follow-up. Main Results: The incidence rate of COPD was 2.8 cases/1,000/yr (95% confidence interval [CI], 2.3-3.3). Chronic cough/phlegm was an independent and statistically significant predictor of COPD (incidence rate ratio [IRR], 1.85; 95% CI, 1.17-2.93) after adjusting for smoking habits and other potential confounders, whereas dyspnea was not associated with the disease (IRR = 0.98; 95% CI, 0.64-1.50). Subjects who reported chronic cough/phlegm both at baseline and at the follow-up had a nearly threefold-increased risk of developing COPD with respect to asymptomatic subjects (IRR = 2.88; 95% CI, 1.44-5.79). Conclusions: The incidence of COPD is substantial even in young adults. The presence of chronic cough/phlegm identifies a subgroup of subjects with a high risk of developing COPD, independently of smoking habits.
Keyword
- Chronic cough and phlegm
- Chronic obstructive pulmonary disease
- Epidemiology
- Incidence
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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de Marco, Robert ...
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Accordini, Simon ...
-
Cerveri, Isa
-
Corsico, Angelo
-
Antó, Josep M.
-
Künzli, Nino
-
show more...
-
Janson, Christer
-
Sunyer, Jordi
-
Jarvis, Deborah
-
Chinn, Susan
-
Vermeire, Paul
-
Svanes, Cecilie
-
Ackermann-Liebri ...
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Gislason, Thorar ...
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Heinrich, Joachi ...
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Leynaert, B.
-
Neukirch, F.
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Schouten, Jan P.
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Wjst, Matthias
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Burney, Peter
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show less...
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American Journal ...
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Uppsala University