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Motivation for sucr...
Motivation for sucrose in sated rats is predicted by low anxiety-like behavior
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- Alsiö, Johan (författare)
- Uppsala universitet,Funktionell farmakologi
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- Pickering, Chris (författare)
- Uppsala universitet,Funktionell farmakologi
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- Roman, Erika (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Neuropharmacology, Addiction and Behaviour
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- Hulting, Anna-Lena (författare)
- Department of Endocrinology, Metabolism and Diabetology, Karolinska Institutet, Stockholm
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- Lindblom, Jonas (författare)
- Uppsala universitet,Funktionell farmakologi
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- Schiöth, Helgi B (författare)
- Uppsala universitet,Funktionell farmakologi
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(creator_code:org_t)
- Elsevier, 2009
- 2009
- Engelska.
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Ingår i: Neuroscience Letters. - : Elsevier. - 0304-3940 .- 1872-7972. ; 454:3, s. 193-197
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Anxiety has been implicated in obesity and in the overconsumption of highly palatable foods such as those high in fat, sugar, or both. Also, the novelty-seeking trait has been associated with failure in weight-loss programs. The aim of this study was to investigate the associations of experimental anxiety and the self-administration of sucrose and high fat pellets in non-food deprived rats across different operant schedules. Male Wistar rats were subjected to the elevated plus-maze test (EPM) of anxiety-like behavior. The rats were tested for fixed ratio 5 (FR5) and progressive ratio (PR) operant responding for 50% sucrose, 95% sucrose, and high-fat pellets. PR active lever press response for 95% sucrose, but not the other pellet types, was correlated to % time spent on open arms (P=0.019) in the EPM. On the FR5 schedule, activity (closed arm entries) was correlated to the self-administration of 50% sucrose (P=0.027) and high-fat (P=0.002). This indicates an association of novelty-induced activity and self-administration of palatable food in sated rats, as well as a specific association of PR lever press response for 95% sucrose and low anxiety-like behavior. It has been argued that such active lever press response on PR may be interpreted as craving for the reinforcer; thus, our findings indicate an inverse relationship of experimental anxiety and craving for sucrose. This connection may have implications for human situations, since anxiety and novelty-seeking have been associated with obesity and failure in weight-loss programs.
Nyckelord
- Craving; Sucrose
- Dietary fat
- Progressive ratio
- Anxiety
- Novelty-seeking
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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