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  • Janson, ChristerUppsala universitet,Lungmedicin och allergologi (författare)

The effect of infectious burden on the prevalence of atopy and respiratory allergies in Iceland, Estonia, and Sweden

  • Artikel/kapitelEngelska2007

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2007
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-11786
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-11786URI
  • https://doi.org/10.1016/j.jaci.2007.05.003DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Epidemiologic reports on the effect of microbe exposure on the development of atopy and allergic asthma are inconsistent. Objectives: The study investigates the association between serologic markers of infections and occurrence of atopy, allergic asthma, and rhinitis among adults in Iceland, Sweden, and Estonia. Methods: Individuals (n = 1249; mean age, 42 years) from Iceland, Sweden, and Estonia underwent a structured interview and blood sampling. Specific IgE was measured against 4 allergens, and IgG antibodies were measured against Helicobacter pylori, Toxoplasmosis gondii, hepatitis A virus, herpes simplex virus 1, Chlamydia pneumoniae, EBV, and cytomegalovirus. Results: Nonatopic subjects more often had positive serology for Helicobacter pylori, herpes simplex virus 1, Chlamydia pneumoniae, and cytomegalovirus. Having a low number (≤3) of IgG antibodies against the various infectious agents was an independent risk factor for atopy (odds ratio [OR], 1.43; 95% CI, 1.06-1.93), allergic asthma (OR, 1.82; 95% CI, 1.12-2.98), and allergic rhinitis (OR, 1.69; 95% CI, 1.21-2.37). The proportion of atopy that can be explained by a lower number (≤3) of infections was 6.7% in Iceland, 9.2% in Estonia, and 16.4% in Sweden, and 6.7%, 48.2%, and 33.4% for allergic asthma, respectively. Conclusion: Our data are consistent with cumulative protective effect of infections against atopy and respiratory allergies irrespective of route of infection. Clinical implications: The study indicates what microbes or combination of microbes play a role in the complex interplay between hygiene and allergy and may contribute toward the understanding of the allergy epidemic.Background: Epidemiologic reports on the effect of microbe exposure on the development of atopy and allergic asthma are inconsistent. Objectives: The study investigates the association between serologic markers of infections and occurrence of atopy, allergic asthma, and rhinitis among adults in Iceland, Sweden, and Estonia. Methods: Individuals (n = 1249; mean age, 42 years) from Iceland, Sweden, and Estonia underwent a structured interview and blood sampling. Specific IgE was measured against 4 allergens, and IgG antibodies were measured against Helicobacter pylori, Toxoplasmosis gondii, hepatitis A virus, herpes simplex virus 1, Chlamydia pneumoniae, EBV, and cytomegalovirus. Results: Nonatopic subjects more often had positive serology for Helicobacter pylori, herpes simplex virus 1, Chlamydia pneumoniae, and cytomegalovirus. Having a low number (≤3) of IgG antibodies against the various infectious agents was an independent risk factor for atopy (odds ratio [OR], 1.43; 95% CI, 1.06-1.93), allergic asthma (OR, 1.82; 95% CI, 1.12-2.98), and allergic rhinitis (OR, 1.69; 95% CI, 1.21-2.37). The proportion of atopy that can be explained by a lower number (≤3) of infections was 6.7% in Iceland, 9.2% in Estonia, and 16.4% in Sweden, and 6.7%, 48.2%, and 33.4% for allergic asthma, respectively. Conclusion: Our data are consistent with cumulative protective effect of infections against atopy and respiratory allergies irrespective of route of infection. Clinical implications: The study indicates what microbes or combination of microbes play a role in the complex interplay between hygiene and allergy and may contribute toward the understanding of the allergy epidemic.

Ämnesord och genrebeteckningar

  • Atopy
  • allergic asthma
  • allergic rhinitis
  • hygiene hypothesis
  • infection
  • epidemiology
  • Helicobacter pylori/immunology
  • hepatitis A/immunology
  • Chlamydia pneumoniae/immunology
  • herpes simplex/immunology
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Asbjornsdottir, Hulda (författare)
  • Birgisdottir, Alda (författare)
  • Sigurjonsdottir, R B (författare)
  • Gunnbjörnsdottir, MaríaUppsala universitet,Lungmedicin och allergologi(Swepub:uu)mariagbd (författare)
  • Gislason, D (författare)
  • Olafsson, Isleifur (författare)
  • Cook, E (författare)
  • Jögi, RainUppsala universitet,Lungmedicin och allergologi(Swepub:uu)raijo735 (författare)
  • Gislason, Thorarinn (författare)
  • Thjodleifsson, Bjarni (författare)
  • Uppsala universitetLungmedicin och allergologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Allergy and Clinical Immunology: Elsevier BV120:3, s. 673-6790091-67491097-6825

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