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The effect of infec...
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Janson, ChristerUppsala universitet,Lungmedicin och allergologi
(författare)
The effect of infectious burden on the prevalence of atopy and respiratory allergies in Iceland, Estonia, and Sweden
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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Elsevier BV,2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-11786
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-11786URI
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https://doi.org/10.1016/j.jaci.2007.05.003DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Epidemiologic reports on the effect of microbe exposure on the development of atopy and allergic asthma are inconsistent. Objectives: The study investigates the association between serologic markers of infections and occurrence of atopy, allergic asthma, and rhinitis among adults in Iceland, Sweden, and Estonia. Methods: Individuals (n = 1249; mean age, 42 years) from Iceland, Sweden, and Estonia underwent a structured interview and blood sampling. Specific IgE was measured against 4 allergens, and IgG antibodies were measured against Helicobacter pylori, Toxoplasmosis gondii, hepatitis A virus, herpes simplex virus 1, Chlamydia pneumoniae, EBV, and cytomegalovirus. Results: Nonatopic subjects more often had positive serology for Helicobacter pylori, herpes simplex virus 1, Chlamydia pneumoniae, and cytomegalovirus. Having a low number (≤3) of IgG antibodies against the various infectious agents was an independent risk factor for atopy (odds ratio [OR], 1.43; 95% CI, 1.06-1.93), allergic asthma (OR, 1.82; 95% CI, 1.12-2.98), and allergic rhinitis (OR, 1.69; 95% CI, 1.21-2.37). The proportion of atopy that can be explained by a lower number (≤3) of infections was 6.7% in Iceland, 9.2% in Estonia, and 16.4% in Sweden, and 6.7%, 48.2%, and 33.4% for allergic asthma, respectively. Conclusion: Our data are consistent with cumulative protective effect of infections against atopy and respiratory allergies irrespective of route of infection. Clinical implications: The study indicates what microbes or combination of microbes play a role in the complex interplay between hygiene and allergy and may contribute toward the understanding of the allergy epidemic.Background: Epidemiologic reports on the effect of microbe exposure on the development of atopy and allergic asthma are inconsistent. Objectives: The study investigates the association between serologic markers of infections and occurrence of atopy, allergic asthma, and rhinitis among adults in Iceland, Sweden, and Estonia. Methods: Individuals (n = 1249; mean age, 42 years) from Iceland, Sweden, and Estonia underwent a structured interview and blood sampling. Specific IgE was measured against 4 allergens, and IgG antibodies were measured against Helicobacter pylori, Toxoplasmosis gondii, hepatitis A virus, herpes simplex virus 1, Chlamydia pneumoniae, EBV, and cytomegalovirus. Results: Nonatopic subjects more often had positive serology for Helicobacter pylori, herpes simplex virus 1, Chlamydia pneumoniae, and cytomegalovirus. Having a low number (≤3) of IgG antibodies against the various infectious agents was an independent risk factor for atopy (odds ratio [OR], 1.43; 95% CI, 1.06-1.93), allergic asthma (OR, 1.82; 95% CI, 1.12-2.98), and allergic rhinitis (OR, 1.69; 95% CI, 1.21-2.37). The proportion of atopy that can be explained by a lower number (≤3) of infections was 6.7% in Iceland, 9.2% in Estonia, and 16.4% in Sweden, and 6.7%, 48.2%, and 33.4% for allergic asthma, respectively. Conclusion: Our data are consistent with cumulative protective effect of infections against atopy and respiratory allergies irrespective of route of infection. Clinical implications: The study indicates what microbes or combination of microbes play a role in the complex interplay between hygiene and allergy and may contribute toward the understanding of the allergy epidemic.
Ämnesord och genrebeteckningar
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Atopy
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allergic asthma
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allergic rhinitis
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hygiene hypothesis
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infection
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epidemiology
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Helicobacter pylori/immunology
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hepatitis A/immunology
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Chlamydia pneumoniae/immunology
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herpes simplex/immunology
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Asbjornsdottir, Hulda
(författare)
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Birgisdottir, Alda
(författare)
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Sigurjonsdottir, R B
(författare)
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Gunnbjörnsdottir, MaríaUppsala universitet,Lungmedicin och allergologi(Swepub:uu)mariagbd
(författare)
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Gislason, D
(författare)
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Olafsson, Isleifur
(författare)
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Cook, E
(författare)
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Jögi, RainUppsala universitet,Lungmedicin och allergologi(Swepub:uu)raijo735
(författare)
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Gislason, Thorarinn
(författare)
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Thjodleifsson, Bjarni
(författare)
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Uppsala universitetLungmedicin och allergologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Allergy and Clinical Immunology: Elsevier BV120:3, s. 673-6790091-67491097-6825
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Gislason, D
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Cook, E
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