Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: a prospective population-based study

Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia : a prospective population-based study

Oxidative stress in the brain is suggested to be involved in the pathophysiology of Alzheimer's disease (AD). In this study, serum alpha- and gamma-tocopherol, the two major systemic antioxidants, were analyzed at two examinations of the ULSAM-study, a longitudinal, community-based study of elderly men (age 70, n = 616 and age 77, n = 761). In addition, urinary F2-isoprostane levels, as markers of systemic oxidative stress, were analyzed at the age of 77 in this cohort (n = 679). Cox regression analyses were used to examine associations between serum alpha-, gamma-tocopherol and urinary F2-isoprostane levels and AD, any type of dementia (all-cause dementia) and non-AD dementia. On follow-up (median, 12.3 years), 40 subjects developed AD and 86 subjects developed all-cause dementia. Serum alpha- and gamma-tocopherol or urinary F2-isoprostane levels were not associated with the future risk of AD or dementia. In conclusion, systemic serum alpha- and gamma-tocopherol and urinary F2-isoprostane levels are not associated with the future risk of AD or dementia and do not seem to be useful predictors of clinical AD or dementia.

Kilander, LenaUppsala universitet,Geriatrik(Swepub:uu)lekil226 (författare)
Helmersson, JohannaUppsala universitet,Institutionen för medicinska vetenskaper,Oxidativ stress och inflammation(Swepub:uu)johahelm (författare)
Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andla606 (författare)
Rönnemaa, ElinaUppsala universitet,Geriatrik(Swepub:uu)eliro837 (författare)
Degerman-Gunnarsson, MalinUppsala universitet,Geriatrik (författare)
Sjögren, PerUppsala universitet,Oxidativ stress och inflammation (författare)
Basun, HansUppsala universitet,Geriatrik(Swepub:uu)habas169 (författare)
Lannfelt, LarsUppsala universitet,Geriatrik(Swepub:uu)lalan021 (författare)
Basu, SamarUppsala universitet,Oxidativ stress och inflammation(Swepub:uu)samabasu (författare)
Uppsala universitetGeriatrik (creator_code:org_t)

Av författaren/redakt...: Sundelöf, Johan; Kilander, Lena; Helmersson, Joha ...; Larsson, Anders; Rönnemaa, Elina; Degerman-Gunnars ...; visa fler...; Sjögren, Per; Basun, Hans; Lannfelt, Lars; Basu, Samar; visa färre...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.