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  • Marklund, NiklasUppsala universitet,Neurokirurgi (author)

Increased Cerebral Uptake of [18F]Fluoro-Deoxyglucose but not [1-14C]Glucose Early following Traumatic Brain Injury in Rats

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • Mary Ann Liebert Inc,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-120848
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120848URI
  • https://doi.org/10.1089/neu.2008.0827DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Following experimental and clinical traumatic brain injury (TBI), the local cerebral metabolic rate of glucose (lCMRGlc) is commonly estimated using the 2-[18F]fluoro-2-deoxy-D-glucose (FDG) method. The adequate estimation of lCMRGlc using FDG requires a correction factor, the lumped constant (LC), to convert FDG net uptake into lCMRGlc. The LC, and thus lCMRGlc calculations, requires a "steady state" that may be disrupted following TBI. In the present report, we hypothesized that [1-14C]glucose uptake would accurately reflect glucose dynamics early post-injury and was compared to the regional uptake of FDG in 44 rats subjected to moderate (2.4-2.6 atm) lateral fluid percussion brain injury (FPI) or sham injury. Cortical energy state and adenylate (ATP, ADP, AMP) levels were also measured. Early (7-42 min) after FPI, FDG uptake was increased in the ipsilateral cortex and hippocampus (p<0.05). In contrast, no change in [1-14C]glucose uptake (7 and 17 min) or cortical adenylate content (42 min post-injury) was observed. At 12 hours following FPI, the ipsilateral FDG and [1-14C]glucose uptake was decreased in the cortex and hippocampus and the ipsilateral cortical ATP concentration was decreased in comparison to sham-injured controls (p<0.05). Under the present experimental conditions, the rate of cerebral uptake of FDG and of [1-14C]glucose differs, and indicate that following TBI, regional changes in the LC may occur in the immediate, but not in the late, post-injury phase. These results should be considered when interpreting results obtained using FDG for the estimation of lCMRGlc early following experimental TBI.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sihver, SvenUppsala universitet,Institutionen för biokemi och organisk kemi,Farmakologi (author)
  • Hovda, David (author)
  • Långström, BengtUppsala universitet,Institutionen för biokemi och organisk kemi(Swepub:uu)benglang (author)
  • Watanabe, Yasuyoshi (author)
  • Ronquist, GunnarUppsala universitet,Klinisk kemi(Swepub:uu)guron517 (author)
  • Bergström, MatsUppsala universitet,Institutionen för biokemi och organisk kemi (author)
  • Hillered, LarsUppsala universitet,Neurokirurgi(Swepub:uu)larshill (author)
  • Uppsala universitetNeurokirurgi (creator_code:org_t)

Related titles

  • In:Journal of Neurotrauma: Mary Ann Liebert Inc26:8, s. 1281-12930897-71511557-9042

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