Search: id:"swepub:oai:DiVA.org:uu-120848" >
Increased Cerebral ...
-
Marklund, NiklasUppsala universitet,Neurokirurgi
(author)
Increased Cerebral Uptake of [18F]Fluoro-Deoxyglucose but not [1-14C]Glucose Early following Traumatic Brain Injury in Rats
- Article/chapterEnglish2009
Publisher, publication year, extent ...
-
Mary Ann Liebert Inc,2009
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-120848
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120848URI
-
https://doi.org/10.1089/neu.2008.0827DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Following experimental and clinical traumatic brain injury (TBI), the local cerebral metabolic rate of glucose (lCMRGlc) is commonly estimated using the 2-[18F]fluoro-2-deoxy-D-glucose (FDG) method. The adequate estimation of lCMRGlc using FDG requires a correction factor, the lumped constant (LC), to convert FDG net uptake into lCMRGlc. The LC, and thus lCMRGlc calculations, requires a "steady state" that may be disrupted following TBI. In the present report, we hypothesized that [1-14C]glucose uptake would accurately reflect glucose dynamics early post-injury and was compared to the regional uptake of FDG in 44 rats subjected to moderate (2.4-2.6 atm) lateral fluid percussion brain injury (FPI) or sham injury. Cortical energy state and adenylate (ATP, ADP, AMP) levels were also measured. Early (7-42 min) after FPI, FDG uptake was increased in the ipsilateral cortex and hippocampus (p<0.05). In contrast, no change in [1-14C]glucose uptake (7 and 17 min) or cortical adenylate content (42 min post-injury) was observed. At 12 hours following FPI, the ipsilateral FDG and [1-14C]glucose uptake was decreased in the cortex and hippocampus and the ipsilateral cortical ATP concentration was decreased in comparison to sham-injured controls (p<0.05). Under the present experimental conditions, the rate of cerebral uptake of FDG and of [1-14C]glucose differs, and indicate that following TBI, regional changes in the LC may occur in the immediate, but not in the late, post-injury phase. These results should be considered when interpreting results obtained using FDG for the estimation of lCMRGlc early following experimental TBI.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Sihver, SvenUppsala universitet,Institutionen för biokemi och organisk kemi,Farmakologi
(author)
-
Hovda, David
(author)
-
Långström, BengtUppsala universitet,Institutionen för biokemi och organisk kemi(Swepub:uu)benglang
(author)
-
Watanabe, Yasuyoshi
(author)
-
Ronquist, GunnarUppsala universitet,Klinisk kemi(Swepub:uu)guron517
(author)
-
Bergström, MatsUppsala universitet,Institutionen för biokemi och organisk kemi
(author)
-
Hillered, LarsUppsala universitet,Neurokirurgi(Swepub:uu)larshill
(author)
-
Uppsala universitetNeurokirurgi
(creator_code:org_t)
Related titles
-
In:Journal of Neurotrauma: Mary Ann Liebert Inc26:8, s. 1281-12930897-71511557-9042
Internet link
Find in a library
To the university's database