WFRF:(Larsson Matts)
Sökning: WFRF:(Larsson Matts) > (2010-2014) > Signs of reduced an...
- Bourlev, Vladimir,1947-Uppsala universitet,Obstetrik & gynekologi,Klinisk och experimentell reproduktionsbiologi/Olovsson (författare)
Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
- Elsevier BV,2010
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-120864
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120864URI
- https://doi.org/10.1016/j.fertnstert.2009.02.019DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- OBJECTIVE: To study the concentrations of vascular endothelial growth factor A (VEGF-A), soluble vascular endothelial growth factor receptors-1 and -2 (sVEGFR-1 and -2), angiogenin, and angiopoietin-2 (Ang-2) in serum and peritoneal fluid from healthy controls and women with advanced endometriosis. Further, we addressed the question of whether surgical removal of endometriotic lesions was associated with normalization of the serum concentrations of the same markers. DESIGN: Patients with endometriosis before and after surgery were compared with control patients. SETTING: University Hospital. PATIENT(S): Twenty-one healthy controls and 32 women with advanced endometriosis. INTERVENTION(S): In women with endometriosis we performed surgical removal of endometriotic lesions using laparoscopy. MAIN OUTCOME MEASURE(S): Data on serum and peritoneal fluid concentrations of selected markers in healthy controls and women with endometriosis before surgery and in serum 5 to 7 days after surgery. RESULT(S): Women with endometriosis had elevated levels of VEGF-A, sVEGFR-1, and Ang-2 in serum and all studied markers in peritoneal fluid compared with healthy controls. Surgical removal of endometriotic lesions resulted in decreased serum levels of pro-angiogenic VEGF-A and increased levels of sVEGFR-2 that negatively regulates the action of VEGF. CONCLUSION(S): Women with advanced endometriosis have serum and peritoneal fluid concentrations of several factors involved in the regulation of angiogenesis that differ from those in healthy women, and these changes at least partly normalize within a week after surgical removal of the endometriotic lesions.
Ämnesord och genrebeteckningar
- MEDICINE
- MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Ilyasova, Natalia,1971-Uppsala universitet,Obstetrik & gynekologi,Klinisk och experimentell reproduktionsbiologi/Olovsson(Swepub:uu)natil371 (författare)
- Adamyan, LeylaResearch Centre of Obstetrics, Gynecology and Perinatology, Russian Academy of the Medical Sciences, Moscow, Russia (författare)
- Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andla606 (författare)
- Olovsson, Matts,1958-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson(Swepub:uu)mattolov (författare)
- Uppsala universitetObstetrik & gynekologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Fertility and Sterility: Elsevier BV94:1, s. 52-570015-02821556-5653
Internetlänk
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- Fertility and Sterility (Sök värdpublikationen i LIBRIS)
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- Av författaren/redakt...
- Bourlev, Vladimi ...
- Ilyasova, Natali ...
- Adamyan, Leyla
- Larsson, Anders
- Olovsson, Matts, ...
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- Fertility and St ...
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- Uppsala universitet
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