Oral bacteria: the missing link to ambiguous findings of exhaled nitrogen oxides in cystic fibrosis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Alving Kjell 1959 ) > Oral bacteria :

Details
MARC

Zetterquist, WilhelmDept of Woman and Child Health, Karolinska Institute, Stockholm, Sweden (author)

Oral bacteria : the missing link to ambiguous findings of exhaled nitrogen oxides in cystic fibrosis

Article/chapterEnglish2009

Publisher, publication year, extent ...

Elsevier BV,2009
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-122223
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122223URI
https://doi.org/10.1016/j.rmed.2008.09.009DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:118296774URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

BACKGROUND: Nitrite in exhaled breath condensate (EBC) has been shown to be elevated in cystic fibrosis (CF), while exhaled nitric oxide (FENO) is paradoxically low. This has been argued to reflect increased metabolism of NO while its diffusion is obstructed by mucus. However, we wanted to study the possible influence of salivary nitrite and bacterial nitrate reduction on these parameters in CF patients by the intervention of an anti-bacterial mouthwash. METHODS: EBC and saliva were collected from 15 CF patients (10-43 years) and 15 controls (9-44 years) before and 5 min after a 30s chlorhexidine mouthwash, in parallel with measurements of FENO. Nitrite and nitrate concentrations were measured fluorometrically. RESULTS: EBC nitrite, but not nitrate, was significantly higher in the CF patients (median 3.6 vs 1.3 microM in controls, p<0.05) and decreased after mouthwash in both groups (3.6-1.4 microM, p<0.01; 1.3-0.5 microM, p<0.01). Salivary nitrite correlated significantly to EBC nitrite (r=0.60, p<0.001) and decreased correspondingly after chlorhexidine, whereas salivary nitrate increased. FENO was lower in CF and the difference between patients and controls was accentuated after mouthwash (5.4 vs 8.4 ppb in controls, p<0.05). CONCLUSION: EBC nitrite mainly originates in the pharyngo-oral tract and its increase in CF is possibly explained by a regional change in bacterial activity. The limited lower airway contribution supports the view of a genuinely impaired formation and metabolism of NO in CF, rather than poor diffusion of the molecule.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
Cystic fibrosis
Nitrite
Nitrate
Nitric oxide
Breath condensate
Saliva
MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Marteus, HelenaDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm S-171 77, Sweden (author)
Kalm-Stephens, Pia,1959-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall(Swepub:uu)piaka760 (author)
Näs, ElisabethUppsala universitet,Institutionen för kvinnors och barns hälsa (author)
Nordvall, LennartUppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall(Swepub:uu)lennnord (author)
Johannesson, MarieUppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall(Swepub:uu)marjohan (author)
Alving, Kjell,1959-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall(Swepub:uu)kjeal631 (author)
Dept of Woman and Child Health, Karolinska Institute, Stockholm, SwedenDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm S-171 77, Sweden (creator_code:org_t)

Related titles

In:Respiratory Medicine: Elsevier BV103:2, s. 187-1930954-61111532-3064

Internet link

Find in a library

Respiratory Medicine (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Zetterquist, Wil ...; Marteus, Helena; Kalm-Stephens, P ...; Näs, Elisabeth; Nordvall, Lennar ...; Johannesson, Mar ...; show more...; Alving, Kjell, 1 ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

Articles in the publication: Respiratory Medi ...

By the university: Uppsala University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se