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  • Webb, Ryan (author)

A polymorphism within IL21R confers risk for systemic lupus erythematosus

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • Wiley,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-122921
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122921URI
  • https://doi.org/10.1002/art.24658DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE: Interleukin-21 (IL-21) is a member of the type I cytokine superfamily that has a variety of effects on the immune system, including B cell activation, plasma cell differentiation, and immunoglobulin production. The expression of IL-21 receptor (IL-21R) is reduced in the B cells of patients with systemic lupus erythematosus (SLE), while serum IL-21 levels are increased both in lupus patients and in some murine lupus models. We recently reported that polymorphisms within the IL21 gene are associated with increased susceptibility to SLE. The aim of this study was to examine the genetic association between single-nucleotide polymorphisms (SNPs) within IL21R and SLE. METHODS: We genotyped 17 SNPs in the IL21R gene in 2 large cohorts of lupus patients (a European-derived cohort and a Hispanic cohort) and in ethnically matched healthy controls. RESULTS: We identified and confirmed the association between rs3093301 within the IL21R gene and SLE in the 2 cohorts (meta-analysis odds ratio 1.16 [95% confidence interval 1.08-1.25], P=1.0x10(-4)). CONCLUSION: Our findings indicate that IL21R is a novel susceptibility gene for SLE.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Merrill, Joan T (author)
  • Kelly, Jennifer A (author)
  • Sestak, Andrea (author)
  • Kaufman, Kenneth M (author)
  • Langefeld, Carl D (author)
  • Ziegler, Julie (author)
  • Kimberly, Robert P (author)
  • Edberg, Jeffrey C (author)
  • Ramsey-Goldman, Rosalind (author)
  • Petri, Michelle (author)
  • Reveille, John D (author)
  • Alarcón, Graciela S (author)
  • Vilá, Luis M (author)
  • Alarcón-Riquelme, Marta EUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)martaala (author)
  • James, Judith A (author)
  • Gilkeson, Gary S (author)
  • Jacob, Chaim O (author)
  • Moser, Kathy L (author)
  • Gaffney, Patrick M (author)
  • Vyse, Timothy J (author)
  • Nath, Swapan K (author)
  • Lipsky, Peter (author)
  • Harley, John B (author)
  • Sawalha, Amr H (author)
  • Uppsala universitetInstitutionen för genetik och patologi (creator_code:org_t)

Related titles

  • In:Arthritis and Rheumatism: Wiley60:8, s. 2402-24070004-35911529-0131

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