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CALHM1 P86L polymor...
CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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- Glaser, Anna (author)
- Uppsala universitet,Geriatrik
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Sarajärvi, Timo (author)
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- Brundin, RoseMarie (author)
- Uppsala universitet,Geriatrik
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- Gunnarsson, Malin Degerman (author)
- Uppsala universitet,Geriatrik
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Schjeide, Brit-Maren (author)
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Tanzi, Rudolph E (author)
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Helisalmi, Seppo (author)
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Pirttilä, Tuula (author)
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- Kilander, Lena (author)
- Uppsala universitet,Geriatrik
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
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Soininen, Hilkka (author)
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Bertram, Lars (author)
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- Ingelsson, Martin (author)
- Uppsala universitet,Geriatrik
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Hiltunen, Mikko (author)
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: Neuroscience Letters. - : Elsevier BV. - 0304-3940 .- 1872-7972. ; 469:2, s. 265-267
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Recently, the P86L alteration in CALHM1 (calcium homeostasis modulator-1) was reported to be associated with Alzheimer's disease (AD). Moreover, the risk allele increased amyloid-beta (A beta) levels in conditioned media from cultured cells. Therefore, we hypothesized that CALHM1 P86L may modulate A beta or tau levels in cerebrospinal fluid (CSF). Nearly 200 individuals with AD or other cognitive disorders were included for CSF analysis and CALHM1 genotyping. No significant differences in CSF levels of A beta 42, tau or phospho-tau were found across the various CALHM1 genotypes. In conclusion, we found no evidence that CALHM1 P86L is associated with altered CSF levels of the investigated AD biomarkers.
Keyword
- Alzheimer's disease
- Amyloid-β
- Biomarker
- Calcium homeostasis modulator-1
- CALHM1
- Cerebrospinal fluid
- Genotyping SNP
- Phospho-tau
- Total tau
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Giedraitis, Vilm ...
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Glaser, Anna
-
Sarajärvi, Timo
-
Brundin, RoseMar ...
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Gunnarsson, Mali ...
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Schjeide, Brit-M ...
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show more...
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Tanzi, Rudolph E
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Helisalmi, Seppo
-
Pirttilä, Tuula
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Kilander, Lena
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Lannfelt, Lars
-
Soininen, Hilkka
-
Bertram, Lars
-
Ingelsson, Marti ...
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Hiltunen, Mikko
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show less...
- Articles in the publication
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Neuroscience Let ...
- By the university
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Uppsala University