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Neuropeptide Y and ...
Neuropeptide Y and gamma-melanocyte stimulating hormone (gamma-MSH) share a common pressor mechanism of action
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Gruber, Kenneth A (författare)
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Fan, Wei (författare)
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- Åkerberg, Helena (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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- Larhammar, Dan, 1956- (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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Chee, Melissa J S (författare)
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Colmers, William F (författare)
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Cone, Roger D (författare)
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(creator_code:org_t)
- 2009-04-11
- 2009
- Engelska.
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Ingår i: Endocrine. - : Springer Science and Business Media LLC. - 1355-008X .- 1559-0100. ; 35:3, s. 312-324
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Central circuits known to regulate food intake and energy expenditure also affect central cardiovascular regulation. For example, both the melanocortin and neuropeptide Y (NPY) peptide families, known to regulate food intake, also produce central hypertensive effects. Members of both families share a similar C-terminal amino acid residue sequence, RF(Y) amide, a sequence distinct from that required for melanocortin receptor binding. A recently delineated family of RFamide receptors recognizes both of these C-terminal motifs. We now present evidence that an antagonist with Y1 and RFamide receptor activity, BIBO3304, will attenuate the central cardiovascular effects of both gamma-melanocyte stimulating hormone (gamma-MSH) and NPY. The use of synthetic melanocortin and NPY peptide analogs excluded an interaction with melanocortin or Y family receptors. We suggest that the anatomical convergence of NPY and melanocortin neurons on cardiovascular control centers may have pathophysiological implications through a common or similar RFamide receptor(s), much as they converge on other nuclei to coordinately control energy homeostasis.
Nyckelord
- gamma-MSH
- Neuropeptide Y
- Hypertensive effects
- Central nervous system
- RFamide peptides
- RFamide receptors
- Y1 antagonists
- Central vasopressin system
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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