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  • Grünblatt, Edna (author)

Tryptophan is a marker of human postmortem brain tissue quality

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • Wiley,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-124219
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124219URI
  • https://doi.org/10.1111/j.1471-4159.2009.06233.xDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Postmortem human brain tissue is widely used in neuroscience research, but use of tissue originating from different brain bank centers is considered inaccurate because of possible heterogeneity in sample quality. There is thus a need for well-characterized markers to assess the quality of postmortem brain tissue. Toward this aim, we determined tryptophan (TRP) concentrations, phosphofructokinase-1 and glutamate decarboxylase activities in 119 brain tissue samples. These neurochemical parameters were tested in samples from autopsied individuals, including control and pathological cases provided by 10 different brain bank centers. Parameters were assessed for correlation with agonal state, postmortem interval, age and gender, brain region, preservation and freezing methods, storage conditions and storage time, RNA integrity, and tissue pH value. TRP concentrations were elevated significantly (p = 0.045) with increased postmortem interval; which might indicate increased protein degradation. Therefore, TRP concentration might be one useful and convenient marker for estimating the quality of human postmortem brain tissue.

Subject headings and genre

  • brain
  • glutamate decarboxylase
  • phosphofructokinase-1
  • postmortem
  • tryptophan
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Monoranu, Camelia Maria (author)
  • Apfelbacher, Manuela (author)
  • Keller, Daniela (author)
  • Michel, Tanja M (author)
  • Alafuzoff, IrinaUppsala universitet,Institutionen för genetik och patologi,Department of Clinical Medicine, Kuopio University, Kuopio, Finland(Swepub:uu)irial548 (author)
  • Ferrer, Isidro (author)
  • Al-Saraj, Safa (author)
  • Keyvani, Kathy (author)
  • Schmitt, Andrea (author)
  • Falkai, Peter (author)
  • Schittenhelm, Jens (author)
  • McLean, Catriona (author)
  • Halliday, Glenda M (author)
  • Harper, Clive (author)
  • Deckert, Jürgen (author)
  • Roggendorf, Wolfgang (author)
  • Riederer, Peter (author)
  • Uppsala universitetInstitutionen för genetik och patologi (creator_code:org_t)

Related titles

  • In:Journal of Neurochemistry: Wiley110:5, s. 1400-14080022-30421471-4159

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