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The effect of acamp...
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Hammarberg, AndersKarolinska Institutet
(author)
The effect of acamprosate on alcohol craving and correlation with hypothalamic pituitary adrenal (HPA) axis hormones and beta-endorphin
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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Elsevier BV,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-124363
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124363URI
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https://doi.org/10.1016/j.brainres.2009.09.093DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119811965URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Acamprosate is a widely utilized, efficacious treatment for relapse prevention in alcohol dependent patients. The mechanism of acamprosate action is hypothesized to be by modulation of craving responses. Previous research has suggested that acamprosate may affect the hypothalamic pituitary adrenal (HPA) axis as well as beta-endorphin. The aim of the present study was to investigate if acamprosate attenuates alcohol craving following a short-term treatment, and if craving and drinking measures are correlated to changes in HPA-axis hormones and beta-endorphin. In a double-blind design, 56 alcohol dependent treatment seeking patients were randomized to 21 days of either acamprosate (1998 mg/day) or placebo treatment. Subjective, physiological and biological measurements were recorded at inclusion and on day 21. The results showed that acamprosate treated patients showed significantly reduced craving compared to placebo. Further, a significant correlation was shown between craving and alcohol consumption during study. No changes in hormonal levels were found in acamprosate treated patients compared to placebo.
Subject headings and genre
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Alcohol dependence
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Treatment; Acamprosate
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Craving
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Neuroendocrine
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HPA
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Pharmaceutical pharmacology
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Farmaceutisk farmakologi
Added entries (persons, corporate bodies, meetings, titles ...)
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Nylander, IngridUppsala universitet,Institutionen för farmaceutisk biovetenskap,Neuropharmacology, Addiction & Behaviour(Swepub:uu)iny08577
(author)
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Zhou, QinUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)qinzhou
(author)
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Jayaram-Lindström, NityaKarolinska Institutet
(author)
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Reid, Malcolm S
(author)
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Franck, JohanKarolinska Institutet
(author)
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Karolinska InstitutetInstitutionen för farmaceutisk biovetenskap
(creator_code:org_t)
Related titles
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In:Brain Research: Elsevier BV1305:Suppl., s. S2-S60006-89931872-6240
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