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Sökning: L773:1535 4970 > (2005-2009) > Long-term outcomes ...

  • de Marco, Roberto (författare)

Long-term outcomes in mild/moderate chronic obstructive pulmonary disease in the European community respiratory health survey

  • Artikel/kapitelEngelska2009

Förlag, utgivningsår, omfång ...

  • 2009
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-124418
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124418URI
  • https://doi.org/10.1164/rccm.200904-0543OCDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • RATIONALE: Little is known about the long-term outcomes of individuals with mild/moderate chronic obstructive pulmonary disease (COPD) according to spirometric criteria. OBJECTIVES: To test whether nonsmokers and asymptomatic subjects with a spirometric diagnosis of COPD have a steeper decrease in lung function and higher hospitalization rates than subjects without airway obstruction. METHODS: A total of 5,205 subjects without asthma (20-44 years of age) from the general population, with FEV(1) >or= 50% predicted at baseline, were followed for 9 years in the frame of an international cohort study. Percent decrease in FEV(1) (DeltaFEV(1)%) and the annual hospitalization rate for respiratory causes during the follow-up were assessed for each subject. MEASUREMENTS AND MAIN RESULTS: At baseline, 324 (6.2%) subjects had the prebronchodilator FEV(1)/FVC ratio less than the lower limit of normal (LLN-COPD), and 105 (2.0%) subjects had the same ratio less than 0.70 (modified GOLD-COPD). At follow-up, smokers with LLN-COPD (n = 205) had a greater mean DeltaFEV(1)% (1.7%; 95% confidence interval [CI], 0.8-2.7) and a higher hospitalization rate (rate ratio [RR], 2.52; 95% CI, 1.65-3.86) than normal subjects. Similarly, symptomatic subjects with LLN-COPD (n = 104) had DeltaFEV(1)% (2.0%; 95% CI, 0.8-3.3) and the hospitalization rate (RR, 4.18; 95% CI, 2.43-7.21) higher than the reference group. By contrast, nonsmokers and asymptomatic subjects with LLN-COPD had outcomes that were similar or even better than normal subjects. Among subjects with LLN-COPD, the association of symptoms with DeltaFEV(1)% varied according to smoking habits (P = 0.007); it was particularly strong in symptomatic smokers and disappeared in symptomatic nonsmokers. Similar results were found with the modified GOLD classification. CONCLUSIONS: In relatively young populations, COPD is associated with poor long-term outcomes in smokers and in symptomatic subjects only.

Ämnesord och genrebeteckningar

  • COPD
  • cohort studies
  • spirometry
  • hospitalization
  • smoking
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Accordini, Simone (författare)
  • Antò, Josep M (författare)
  • Gislason, Thorarinn (författare)
  • Heinrich, Joachim (författare)
  • Janson, ChristerUppsala universitet,Lungmedicin och allergologi(Swepub:uu)chrisjn (författare)
  • Jarvis, Deborah (författare)
  • Künzli, Nino (författare)
  • Leynaert, Bénédicte (författare)
  • Marcon, Alessandro (författare)
  • Sunyer, Jordi (författare)
  • Svanes, Cecilie (författare)
  • Wjst, Matthias (författare)
  • Burney, Peter (författare)
  • Uppsala universitetLungmedicin och allergologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:American Journal of Respiratory and Critical Care Medicine180:10, s. 956-9631073-449X1535-4970

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