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Safety and efficacy...
Safety and efficacy of drug-eluting vs. bare metal stents in patients with diabetes mellitus : long-term follow-up in the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)
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- Stenestrand, Ulf (author)
- Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken
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- James, Stefan K., 1964- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),Uppsala Clinical Research Centre
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- Lindbäck, Johan (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala Clinical Research Centre
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- Fröbert, Ole (author)
- Department of Cardiology, Orebro, Sweden
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- Carlsson, Jörg (author)
- Department of Cardiology, Kalmar, Sweden
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- Scherstén, Fredrik (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Cardiology, Lund, Sweden
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- Nilsson, Tage (author)
- Department of Cardiology, Karlstad, Sweden
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- Lagerqvist, Bo, 1952- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),Uppsala Clinical Research Centre
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(creator_code:org_t)
- 2009-11-10
- 2010
- English.
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In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 31:2, s. 177-186
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http://dx.doi.org/10...
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Abstract
Subject headings
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- AIMS: Patients with diabetes mellitus have more extensive coronary artery disease, more disease progression, and restenosis. The use of drug-eluting stents (DES) in these patients is widespread, despite uncertain long-term safety and efficacy. METHODS AND RESULTS: All consecutive patients with diabetes mellitus in Sweden who underwent percutaneous coronary intervention were entered into the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) during 2003-06 with complete follow-up for 1-4 years (median 2.5). Patients who received at least one DES (n = 4754) were compared with those who received only bare metal stents (BMS) (n = 4956) at the index procedure. Combined outcome of death or myocardial infarction (MI) showed no difference for DES vs. BMS, relative risk (RR), 0.91 [95% confidence interval (CI), 0.77-1.06]. Myocardial infarction was significantly less common with DES in patients who received only one stent RR, 0.80 (95% CI, 0.66-0.96). The restenosis rate was 50% lower in DES-treated patients RR, 0.50 (95% CI, 0.35-0.70) and was associated with a higher adjusted RR of MI, RR, 5.03 (95% CI, 4.25-5.97). DES was associated with reduced restenosis rates in all subgroups of diabetic patients with the greatest benefit in stent diameters <3 mm or stent length >20 mm. The number of lesions treated with DES to prevent one restenosis ranged from 11 to 47 in various subgroups. CONCLUSION: This real-life registry study shows that restenosis was halved by DES in diabetic patients with stable or unstable coronary disease, with similar risk of death or MI up to 4 years compared with BMS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Diabetes mellitus
- Drug-eluting stent
- Mortality
- Myocardial infarction
- Outcome
- Percutaneous coronary intervention
- Revascularization
- MEDICINE
- MEDICIN
- Percutaneous coronary intervention
- Revascularization
- Drug-eluting stent
- Mortality
- Diabetes mellitus
- Outcome
- Myocardial infarction
Publication and Content Type
- ref (subject category)
- art (subject category)
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