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  • Littorin, BengtLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine (author)

Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects : results from the nationwide Diabetes Incidence Study in Sweden (DISS)

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • 2006-10-27
  • Springer Science and Business Media LLC,2006
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-124768
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124768URI
  • https://doi.org/10.1007/s00125-006-0426-xDOI
  • https://lup.lub.lu.se/record/163566URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-14161URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1931866URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-37791URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Low plasma vitamin D concentrations may promote the development of type 1 diabetes. To test this hypothesis, we measured plasma 25-hydroxyvitamin D (25OHD) in young adults with type 1 diabetes.The nationwide Diabetes Incidence Study in Sweden (DISS) covers 15- to 34-year-old people with newly diagnosed diabetes. Blood samples at diagnosis were collected during the 2-year period 1987/1988. Patients with islet antibodies (islet cell antibodies, GAD antibodies or tyrosine phosphatase-like protein antibodies) were defined as having autoimmune type 1 diabetes. Plasma 25OHD was measured in samples taken from 459 patients at the time of diagnosis, and in 138 of these subjects 8 years later. The results were compared with age- and sex-matched control subjects (n=208).At diagnosis, plasma 25OHD levels were significantly lower in patients with type 1 diabetes than in control subjects (82.5 +/- 1.3 vs 96.7 +/- 2.0 nmol/l; p < 0.0001). Eight years later, plasma 25OHD had decreased in patients (81.5 +/- 2.6 nmol/l; p=0.04). Plasma 25OHD levels were significantly lower in diabetic men than in diabetic women at diagnosis (77.9 +/- 1.4 vs 90.1 +/- 2.4 nmol/l; p < 0.0001) and at follow-up (77.1 +/- 2.8 nmol/l vs 87.2 +/- 4.5 nmol/l; p=0.048). 81.5 +/- 2.6 nmol/l; p=0.04). Plasma 25OHD levels were significantly lower in diabetic men than in diabetic women at diagnosis (77.9 +/- 1.4 vs 90.1 +/- 2.4 nmol/l; p < 0.0001) and at follow-up (77.1 +/- 2.8 nmol/l vs 87.2 +/- 4.5 nmol/l; p=0.048). Conclusions/interpretation The plasma 25OHD level was lower at diagnosis of autoimmune type 1 diabetes than in control subjects, and may have a role in the development of type 1 diabetes. Plasma 25OHD levels were lower in men than in women with type 1 diabetes. This difference may be relevant to the high incidence of type 1 diabetes among young adult men.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Blom, P. (author)
  • Schölin, AnnaUppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi and diabetes (author)
  • Arnqvist, Hans,1943-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för medicinsk cellbiologi,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)hanar64 (author)
  • Blohmé, G. (author)
  • Bolinder, J.Karolinska Institutet (author)
  • Ekbom-Schnell, AnnikaUppsala universitet,Institutionen för medicinska vetenskaper (author)
  • Eriksson, Jan W.Umeå universitet,Medicin(Swepub:umu)jaer0001 (author)
  • Gudbjörnsdottir, S. (author)
  • Nyström, LennarthUmeå universitet,Epidemiologi och folkhälsovetenskap(Swepub:umu)leny0002 (author)
  • Östman, J. (author)
  • Sundkvist, GöranLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-gsu (author)
  • Institutionen för kliniska vetenskaper, MalmöMedicinska fakulteten (creator_code:org_t)

Related titles

  • In:Diabetologia: Springer Science and Business Media LLC49:12, s. 2847-28520012-186X1432-0428

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