Search: id:"swepub:oai:DiVA.org:uu-124768" >
Lower levels of pla...
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Littorin, BengtLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
(author)
Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects : results from the nationwide Diabetes Incidence Study in Sweden (DISS)
- Article/chapterEnglish2006
Publisher, publication year, extent ...
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2006-10-27
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Springer Science and Business Media LLC,2006
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-124768
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124768URI
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https://doi.org/10.1007/s00125-006-0426-xDOI
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https://lup.lub.lu.se/record/163566URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-14161URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1931866URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-37791URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Low plasma vitamin D concentrations may promote the development of type 1 diabetes. To test this hypothesis, we measured plasma 25-hydroxyvitamin D (25OHD) in young adults with type 1 diabetes.The nationwide Diabetes Incidence Study in Sweden (DISS) covers 15- to 34-year-old people with newly diagnosed diabetes. Blood samples at diagnosis were collected during the 2-year period 1987/1988. Patients with islet antibodies (islet cell antibodies, GAD antibodies or tyrosine phosphatase-like protein antibodies) were defined as having autoimmune type 1 diabetes. Plasma 25OHD was measured in samples taken from 459 patients at the time of diagnosis, and in 138 of these subjects 8 years later. The results were compared with age- and sex-matched control subjects (n=208).At diagnosis, plasma 25OHD levels were significantly lower in patients with type 1 diabetes than in control subjects (82.5 +/- 1.3 vs 96.7 +/- 2.0 nmol/l; p < 0.0001). Eight years later, plasma 25OHD had decreased in patients (81.5 +/- 2.6 nmol/l; p=0.04). Plasma 25OHD levels were significantly lower in diabetic men than in diabetic women at diagnosis (77.9 +/- 1.4 vs 90.1 +/- 2.4 nmol/l; p < 0.0001) and at follow-up (77.1 +/- 2.8 nmol/l vs 87.2 +/- 4.5 nmol/l; p=0.048). 81.5 +/- 2.6 nmol/l; p=0.04). Plasma 25OHD levels were significantly lower in diabetic men than in diabetic women at diagnosis (77.9 +/- 1.4 vs 90.1 +/- 2.4 nmol/l; p < 0.0001) and at follow-up (77.1 +/- 2.8 nmol/l vs 87.2 +/- 4.5 nmol/l; p=0.048). Conclusions/interpretation The plasma 25OHD level was lower at diagnosis of autoimmune type 1 diabetes than in control subjects, and may have a role in the development of type 1 diabetes. Plasma 25OHD levels were lower in men than in women with type 1 diabetes. This difference may be relevant to the high incidence of type 1 diabetes among young adult men.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Blom, P.
(author)
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Schölin, AnnaUppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi and diabetes
(author)
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Arnqvist, Hans,1943-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för medicinsk cellbiologi,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)hanar64
(author)
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Blohmé, G.
(author)
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Bolinder, J.Karolinska Institutet
(author)
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Ekbom-Schnell, AnnikaUppsala universitet,Institutionen för medicinska vetenskaper
(author)
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Eriksson, Jan W.Umeå universitet,Medicin(Swepub:umu)jaer0001
(author)
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Gudbjörnsdottir, S.
(author)
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Nyström, LennarthUmeå universitet,Epidemiologi och folkhälsovetenskap(Swepub:umu)leny0002
(author)
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Östman, J.
(author)
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Sundkvist, GöranLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-gsu
(author)
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Institutionen för kliniska vetenskaper, MalmöMedicinska fakulteten
(creator_code:org_t)
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In:Diabetologia: Springer Science and Business Media LLC49:12, s. 2847-28520012-186X1432-0428
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Diabetologia
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