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Enhancing influence...
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Benedict, ChristianDepartment of Neuroendocrinology, University of Lübeck, Lübeck, Germany
(author)
Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-06-22
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FASEB,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-124775
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124775URI
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https://doi.org/10.1096/fj.08-122853DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The cytokine IL-6 has been considered to exert neuromodulating influences on the brain, with promoting influences on sleep. Sleep enhances the consolidation of memories, and, in particular, late nocturnal sleep also represents a period of enhanced IL-6 signaling, due to a distinctly enhanced availability of soluble IL-6 receptors during this period, enabling trans-signaling of IL-6 to neurons. Thus, a contribution of IL-6 to sleep-dependent memory consolidation is hypothesized. To test this hypothesis, we compared effects of intranasally administered IL-6 (vs. placebo) on sleep-dependent consolidation of declarative (neutral and emotional texts, 2-dimensional object location) and procedural (finger sequence tapping) memories in 17 healthy young men. IL-6 distinctly improved the sleep-related consolidation of emotional text material (P<0.03), which benefits mostly from sleep in the second night-half, in which rapid eye movement sleep (REM) dominates the non-REM-REM sleep cycle. During this second night-half, the amount of electroencephalogram slow-wave activity (0.5-4 Hz) distinctly increased after IL-6 (P<0.01). Other types of memory were not affected. The ability of IL-6 to enhance sleep-associated emotional memory consolidation highlights an example of a functional interaction between the central nervous and immune system.
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Scheller, Jürgen
(author)
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Rose-John, Stefan
(author)
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Born, Jan
(author)
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Marshall, Lisa
(author)
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Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany
(creator_code:org_t)
Related titles
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In:The FASEB Journal: FASEB23:10, s. 3629-36360892-66381530-6860
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