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  • Järnum, Hanna (author)

Perfusion MRI of brain tumours : a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2009-10-20
  • Springer Science and Business Media LLC,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-124861
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124861URI
  • https://doi.org/10.1007/s00234-009-0616-6DOI
  • https://lup.lub.lu.se/record/1588235URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • INTRODUCTION: The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours. METHODS: A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brain coverage. The visual qualitative evaluation of signal enhancement in tumour was scored from 0 to 3 (0 = no signal enhancement compared with white matter, 3 = pronounced signal enhancement with equal or higher signal intensity than in grey matter/basal ganglia). The extent of susceptibility artefacts in the tumour was scored from 0 to 2 (0 = no susceptibility artefacts and 2 = extensive susceptibility artefacts (maximum diameter > 2 cm)). A quantitative analysis was performed with normalised tumour blood flow values (ASL nTBF, DSC nTBF): mean value for region of interest (ROI) in an area with maximum signal enhancement/the mean value for ROIs in cerebellum. RESULTS: There was no difference in total visual score for signal enhancement between PC ASL and DSC relative cerebral blood flow (p = 0.12). ASL had a lower susceptibility-artefact score than DSC-MRI (p = 0.03). There was good correlation between DSC nTBF and ASL nTBF values with a correlation coefficient of 0.82. CONCLUSION: PC ASL is an alternative to DSC-MRI for the evaluation of perfusion in brain tumours. The method has fewer susceptibility artefacts than DSC-MRI and can be used in patients with renal failure because no contrast injection is needed.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Steffensen, Elena G. (author)
  • Knutsson, LindaLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)rafy-lan (author)
  • Fründ, Ernst-Torben (author)
  • Simonsen, Carsten Wiberg (author)
  • Lundbye-Christensen, Søren (author)
  • Shankaranarayanan, Ajit (author)
  • Alsop, David C. (author)
  • Jensen, Finn Taagehøj (author)
  • Larsson, Elna-MarieUppsala universitet,Enheten för radiologi(Swepub:uu)elnla305 (author)
  • Medicinsk strålningsfysik, LundSektion V (creator_code:org_t)

Related titles

  • In:Neuroradiology: Springer Science and Business Media LLC52:4, s. 307-3170028-39401432-1920

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