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Use of a commercial...
Use of a commercial line blot assay as a screening test for autoantibodies in inflammatory myopathies
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- Rönnelid, Johan (författare)
- Uppsala universitet,Enheten för klinisk immunologi,Johan Rönnelid
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- Barbasso Helmers, Sevim (författare)
- Karolinska Institutet
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- Storfors, Helena (författare)
- Uppsala universitet,Enheten för klinisk immunologi
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- Grip, Katarina (författare)
- Uppsala universitet,Enheten för klinisk immunologi
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- Rönnblom, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Franck-Larsson, Karin (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Nordmark, Gunnel (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Lundberg, Iingrid E. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: Autoimmunity Reviews. - : Elsevier BV. - 1568-9972 .- 1873-0183. ; 9:1, s. 58-61
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- AIMS: To evaluate the clinical utility of a commercial immunoblot assay for the detection of myositis-specific autoantibodies. METHODS: Serum samples from 153 myositis patients and 77 disease controls were investigated. The commercial Euroline assay with seven autoantigens (Mi-2, Ku, PM-Scl, Jo-1, Pl-7, Pl-12 and SSA/Ro-52) was used according to the manufacturer s instructions, and supplemented with an anti-SRP strip. In a separate experiment analyses were performed at different temperatures. Results were recorded with densitometry. RESULTS: Anti-Jo-1 was found in 18 myositis and one systemic sclerosis patient. Antibodies against Mi-2 were found in 5 myositis patients, and eleven myositis patients had antibodies against PM-Scl. Four myositis patients showed anti-Pl-7 reactivity, whereas no patients had antibodies against Pl-12. Anti-Ku antibodies were found in 4 myositis and 2 primary Sjögren's syndrome patients. Anti-SRP was found in 8 myositis patients as well as in two disease controls. Antibodies against SSA/Ro52 ranged between 23-62% in all groups except juvenile dermatomyositis patients. Most autoantibody reactivities were clearly positive, only 11% (14/127) were borderline positive. Higher assay temperature increased antibody reactivities. CONCLUSIONS: Except for anti-SSA/Ro-52 and anti-Ku the antibody reactivities were rather myositis-specific, supporting the use of this immunoblot assay. However, assay validation needs to be determined against other methods.
Nyckelord
- Autoantibodies
- Dermatomyositis
- Polymyositis
- Diagnosis
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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