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Venous thromboembol...
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Cohen, Alexander T.
(författare)
Venous thromboembolism (VTE) in Europe : The number of VTE events and associated morbidity and mortality
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-12552
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-12552URI
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https://doi.org/10.1160/TH07-03-0212DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Venous thromboembolism (VTE) is often asymptomatic, mis-diagnosed, and unrecognized at death, and there is a lack of routine postmortem examinations.These factors are thought to result in marked underestimates ofVTE incidence.The objective of our study was to estimate the total burden of VTE within the European Union (EU) per annum. An epidemiological model was constructed to estimate the number of community- and hospital-acquired incidents and recurrent cases (attack rate) of non-fatal VTE and VTE-related deaths, as well as incident and prevalent cases of post-thrombotic syndrome (PTS) and chronic thromboembolic pulmonary hypertension (PH) occurring in the EU per annum. Individual models were developed for six EU countries.The models were populated with data from published literature and, where necessary, expert opinions. The findings were tested using probabilistic sensitivity analyses. The estimated total number of symptomaticVTE events (range based on probabilistic sensitivity analysis) per annum within the six EU countries was 465,715 (404,664-538,189) cases of deep-vein thrombosis, 295,982 (242,450-360,363) cases of pulmonary embolism (PE), and 370,012 (300,193-483,108) VTE-related deaths. Of these deaths, an estimated 27,473 (7%) were diagnosed as being antemortem; 126,145 (34%) were sudden fatal PE, and 217,394 (59%) followed undiagnosed PE.Almost three-quarters of all VTE-related deaths were from hospital-acquired VTE.VTE is a major health problem in the EU,with over one millionVTE events or deaths per annum in the six countries examined. Given the availability of effective VTE prophylaxis, many of these events and deaths could have been prevented.These results have important implications for the allocation of healthcare resources.
Ämnesord och genrebeteckningar
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Respiratory disease
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Venous disease
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Vascular disease
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Cardiovascular disease
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Pulmonary embolism
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Post-thrombotic disease
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Prevention
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Deep vein thrombosis
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Pulmonary hypertension
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Mortality
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Venous thrombosis
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Morbidity
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Europe
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Thromboembolism
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Agnelli, Giancarlo
(författare)
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Anderson, Frederick A.
(författare)
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Arcelus, Juan I.
(författare)
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Bergqvist, DavidUppsala universitet,Institutionen för kirurgiska vetenskaper,Vascular surgery(Swepub:uu)daviberg
(författare)
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Brecht, Josef G.
(författare)
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Greer, Ian A.
(författare)
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Heit, John A.
(författare)
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Hutchinson, Julia L.
(författare)
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Kakkar, Ajay K.
(författare)
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Mottier, Dominique
(författare)
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Oger, Emmanuel
(författare)
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Samama, Meyer-Michel
(författare)
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Spannagl, Michael
(författare)
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Uppsala universitetInstitutionen för kirurgiska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Thrombosis and Haemostasis98:4, s. 756-7640340-62452567-689X
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Cohen, Alexander ...
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Agnelli, Giancar ...
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Anderson, Freder ...
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Arcelus, Juan I.
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Bergqvist, David
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Brecht, Josef G.
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visa fler...
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Greer, Ian A.
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Heit, John A.
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Hutchinson, Juli ...
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Kakkar, Ajay K.
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Mottier, Dominiq ...
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Oger, Emmanuel
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Samama, Meyer-Mi ...
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Spannagl, Michae ...
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visa färre...
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Thrombosis and H ...
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Uppsala universitet