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pH measurement as q...
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Monoranu, Camelia Maria
(author)
pH measurement as quality control on human post mortem brain tissue : a study of the BrainNet Europe consortium
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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Wiley,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-125526
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-125526URI
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https://doi.org/10.1111/j.1365-2990.2008.01003a.xDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171347URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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AIMS: Most brain diseases are complex entities. Although animal models or cell culture experiments mimic some disease aspects, human post mortem brain tissue remains essential to advance our understanding of brain diseases using biochemical and molecular techniques. Post mortem artefacts must be properly understood, standardized, and either eliminated or factored into such experiments. Here we examine the influence of several premortem and post mortem factors on pH, and discuss the role of pH as a biochemical marker for brain tissue quality. METHODS: We assessed brain tissue pH in 339 samples from 116 brains provided by 8 different European and 2 Australian brain bank centres. We correlated brain pH with tissue source, post mortem delay, age, gender, freezing method, storage duration, agonal state and brain ischaemia. RESULTS: Our results revealed that only prolonged agonal state and ischaemic brain damage influenced brain tissue pH next to repeated freeze/thaw cycles. CONCLUSIONS: pH measurement in brain tissue is a good indicator of premortem events in brain tissue and it signals limitations for post mortem investigations.
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Apfelbacher, M.
(author)
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Grünblatt, E.
(author)
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Puppe, B.
(author)
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Alafuzoff, IrinaDepartment of Neuroscience and Neurology, University of Kuopio Finland(Swepub:uu)irial548
(author)
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Ferrer, I.
(author)
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Al-Saraj, S.
(author)
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Keyvani, K.
(author)
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Schmitt, A.
(author)
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Falkai, P.
(author)
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Schittenhelm, J.
(author)
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Halliday, G.
(author)
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Kril, J.
(author)
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Harper, C.
(author)
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McLean, C.
(author)
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Riederer, P.
(author)
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Roggendorf, W.
(author)
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Department of Neuroscience and Neurology, University of Kuopio Finland
(creator_code:org_t)
Related titles
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In:Neuropathology and Applied Neurobiology: Wiley35:3, s. 329-3370305-18461365-2990
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Monoranu, Cameli ...
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Apfelbacher, M.
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Grünblatt, E.
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Puppe, B.
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Alafuzoff, Irina
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Ferrer, I.
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show more...
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Al-Saraj, S.
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Keyvani, K.
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Schmitt, A.
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Falkai, P.
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Schittenhelm, J.
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Halliday, G.
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Kril, J.
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Harper, C.
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McLean, C.
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Riederer, P.
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Roggendorf, W.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Neuropathology a ...
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Uppsala University