WFRF:(Westermark Gunilla T)
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- Westermark, Gunilla T.Linköpings universitet,Uppsala universitet,Institutionen för medicinsk cellbiologi,Cellbiologi,Hälsouniversitetet (author)
Serum amyloid A and protein AA : molecular mechanisms of a transmissible amyloidosis
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- 2009-04-23
- Wiley,2009
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-126019
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126019URI
- https://doi.org/10.1016/j.febslet.2009.04.026DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-21254URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Systemic AA-amyloidosis is a complication of chronic inflammatory diseases and the fibril protein AA derives from the acute phase reactant serum AA. AA-amyloidosis can be induced in mice by an inflammatory challenge. The lag phase before amyloid develops can be dramatically shortened by administration of a small amount of amyloid fibrils. Systemic AA-amyloidosis is transmissible in mice and may be so in humans. Since transmission can cross species barriers it is possible that AA-amyloidosis can be induced by amyloid in food, e.g. foie gras. In mice, development of AA-amyloidosis can also be accelerated by other components with amyloid-like properties. A new possible risk factor may appear with synthetically made fibrils from short peptides, constructed for tissue repair.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Amyloid; Fibril; Prion; Transmission; Seeding
- Dermatology and venerology
- Dermatologi och venerologi
- Pathology
- Patologi
- Pathology
- Patologi
- MEDICINE
Added entries (persons, corporate bodies, meetings, titles ...)
- Westermark, PerUppsala universitet,Institutionen för genetik och patologi,Per Westermark,Uppsala University(Swepub:uu)perweste (author)
- Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)
Related titles
- In:FEBS Letters: Wiley583:16, s. 2685-26900014-57931873-3468
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