Sökning: WFRF:(Juntti Berggren Lisa) >
Antiviral treatment...
-
Holmberg, Rebecka
(författare)
Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
-
Wiley,2009
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-127514
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-127514URI
-
https://doi.org/10.1111/j.1348-0421.2009.00160.xDOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:119396952URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
The effects of LV in two different species, CD-1 mice, without a genetic disposition for diabetes, and BB rats prone to T1D were examined. Male CD-1 mice that had been exposed to LV in utero developed a type 2-like diabetes with increased blood glucose, insulin levels and epididymal fat at the age of 10-15 weeks. Combination therapy including LV-antiserum and an antiviral drug, Pleconaril, significantly reduced the levels of blood glucose and insulin and the amount of abdominal fat. In BB rats, LV has been found in both prediabetic- and diabetic diabetes-prone rats, as well as in diabetes-resistant rats. To evaluate whether the presence of LV has any influence on the onset of T1D, prediabetic BB rats were treated with an antiserum against LV or a combination of the antiviral drugs Pleconaril and Ribavirin. In the group treated with antiviral drugs, the onset was significantly delayed. These results indicate that the presence of LV can be involved in the pathogenesis of diabetes in these animal models.
Ämnesord och genrebeteckningar
-
antibody treatment
-
antiviral therapy
-
viral infection
-
MEDICINE
-
MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Klitz, William
(författare)
-
Blixt, MartinUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)mabli254
(författare)
-
Berggren, Per-OlofKarolinska Institutet
(författare)
-
Juntti-Berggren, LisaKarolinska Institutet
(författare)
-
Niklasson, BoUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)boani125
(författare)
-
Uppsala universitetInstitutionen för medicinsk cellbiologi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Microbiology and immunology: Wiley53:10, s. 567-5720385-56001348-0421
Internetlänk
Hitta via bibliotek
Till lärosätets databas