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Temozolomide as mon...
Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors
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- Ekeblad, Sara (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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- Sundin, Anders (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Janson, Eva Tiensuu (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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- Welin, Staffan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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- Granberg, Dan (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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- Kindmark, Henrik (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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- Dunder, Kristina (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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- Kozlovacki, Gordana (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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- Örlefors, Håkan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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- Sigurd, Mattias (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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- Öberg, Kjell (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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- Eriksson, Barbro (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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- Skogseid, Britt (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Tumörbiologisk endokrinologi
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 13:10, s. 2986-2991
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Purpose: A retrospective analysis of the toxicity and efficacy of temozolomide in advanced neuroendocrine tumors. Experimental Design: Thirty-six patients with advanced stages of neuroendocrine tumor (1 gastric, 7 thymic and 13 bronchial carcinoids, 12 pancreatic endocrine tumors, 1 paraganglioma, 1 neuroendocrine foregut, and 1 neuroendocrine cecal cancer) were treated with temozolomide (200 mg/m2) for 5 days every 4 weeks. Patients had previously received a mean of 2.4 antitumoral medical regimens. Tumor response was evaluated radiologically according to the Response Evaluation Criteria in Solid Tumors every 3 months on an intent-to-treat basis. The circulating tumor marker plasma chromogranin A was also assessed. The expression of 06-methylguanine DNA methyltransferase, an enzyme implicated in chemotherapy resistance, was studied by immunohistochemistry (n = 23) and compared with response to temozolomide. Results: Median overall time to progression was 7 months (95% confidence interval, 3-10). Radiologic response was seen in 14% of patients and stable disease in 53%. Side effects were mainly hematologic; 14% experienced grade 3 or 4 thrombocytopenia (National Cancer Institute toxicity criteria). Ten patients had tumors with 06-methylguanine DNA methyltransferase immunoreactivity in <10% of nuclei, whereas four patients showed radiologic responses. Conclusions: Temozolomide as monotherapy had acceptable toxicity and antitumoral effects in a small series of patients with advanced malignant neuroendocrine tumors and four of these showed radiologic responses.
Keyword
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Ekeblad, Sara
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Sundin, Anders
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Janson, Eva Tien ...
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Welin, Staffan
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Granberg, Dan
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Kindmark, Henrik
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Dunder, Kristina
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Kozlovacki, Gord ...
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Örlefors, Håkan
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Sigurd, Mattias
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Öberg, Kjell
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Eriksson, Barbro
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Skogseid, Britt
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- Articles in the publication
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Clinical Cancer ...
- By the university
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Uppsala University
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Karolinska Institutet