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Search: WFRF:(Knowles R.) > (2005-2009) > Common polygenic va...

  • Purcell, Shaun M. (author)

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-07-01
  • Springer Science and Business Media LLC,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-128329
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128329URI
  • https://doi.org/10.1038/nature08185DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119170677URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%(1,2). We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wray, R (author)
  • Stone, L (author)
  • Visscher, M (author)
  • O'Donovan, C (author)
  • Sullivan, F (author)
  • Sklar, Pamela (author)
  • Ruderfer, M (author)
  • McQuillin, Andrew (author)
  • Morris, W (author)
  • O'Dushlaine, T (author)
  • Corvin, Aiden (author)
  • Holmans, A (author)
  • Macgregor, Stuart (author)
  • Gurling, Hugh (author)
  • Blackwood, R (author)
  • Craddock, J (author)
  • Gill, Michael (author)
  • Hultman, Christina M.Karolinska Institutet,Uppsala universitet,Institutionen för neurovetenskap (author)
  • Kirov, K (author)
  • Lichtenstein, PaulKarolinska Institutet (author)
  • Muir, J (author)
  • Owen, J (author)
  • Pato, N (author)
  • Scolnick, M (author)
  • St Clair, David (author)
  • Williams, M (author)
  • Georgieva, Lyudmila (author)
  • Nikolov, Ivan (author)
  • Norton, N (author)
  • Williams, H (author)
  • Toncheva, Draga (author)
  • Milanova, Vihra (author)
  • Thelander, F (author)
  • Sullivan, Patrick (author)
  • Kenny, Elaine (author)
  • Quinn, M (author)
  • Choudhury, Khalid (author)
  • Datta, Susmita (author)
  • Pimm, Jonathan (author)
  • Thirumalai, Srinivasa (author)
  • Puri, Vinay (author)
  • Krasucki, Robert (author)
  • Lawrence, Jacob (author)
  • Quested, Digby (author)
  • Bass, Nicholas (author)
  • Crombie, Caroline (author)
  • Fraser, Gillian (author)
  • Kuan, Leh (author)
  • Walker, Nicholas (author)
  • McGhee, A (author)
  • Pickard, Ben (author)
  • Malloy, Pat (author)
  • Maclean, W (author)
  • Van Beck, Margaret (author)
  • Pato, T (author)
  • Medeiros, Helena (author)
  • Middleton, Frank (author)
  • Carvalho, Celia (author)
  • Morley, Christopher (author)
  • Fanous, Ayman (author)
  • Conti, David (author)
  • Knowles, A (author)
  • Ferreira, Paz (author)
  • Macedo, Antonio (author)
  • Azevedo, Helena (author)
  • Kirby, N (author)
  • Ferreira, R (author)
  • Daly, J (author)
  • Chambert, Kimberly (author)
  • Kuruvilla, Finny (author)
  • Gabriel, B (author)
  • Ardlie, Kristin (author)
  • Moran, Jennifer L. (author)
  • Uppsala universitetInstitutionen för neurovetenskap (creator_code:org_t)

Related titles

  • In:Nature: Springer Science and Business Media LLC460:7256, s. 748-7520028-08361476-4687

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