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- Aghajanova, LusineDept of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, USA (author)
Diminished endometrial expression of ghrelin and ghrelin receptor contributes to infertility
- Article/chapterEnglish2010
Publisher, publication year, extent ...
- 2010-12-30
- Springer Science and Business Media LLC,2010
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-129820
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-129820URI
- https://doi.org/10.1177/1933719110371683DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:121308151URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- The objectives were to investigate the presence, distribution and sex steroid hormone regulation of ghrelin and its receptor, growth hormone secretagogue receptor (GHSR), in human endometrium in relation to endometrial receptivity and fertility. Endometrial biopsies were obtained from women with unexplained infertility and healthy fertile volunteers. Ishikawa cells were used to mimic the action of ghrelin in endometrium. Immunostaining of GHSR was strong in luminal epithelium and stroma during mid-secretory phase. Ghrelin and GHSR expression is less intense in mid-secretory endometrium of infertile women compared to fertile controls. Treatment with estrogen and/or progesterone or their antagonists did not significantly change the relative expression of GHSR in Ishikawa and stromal cells. Ghrelin was present in and secreted from human blastocysts, which suggest that the communication between human blastocyst and endometrium might involve ghrelin. Low levels of GHSR in endometrium from women with unexplained infertility may in part explain the infertility.
Subject headings and genre
- Ghrelin
- GHSR
- endometrium
- unexplained infertility
- estrogen
- progesterone
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Rumman, AmaniUppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson (author)
- Altmäe, SigneKarolinska Institutet (author)
- Wånggren, KjellUppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson(Swepub:uu)kjewa145 (author)
- Stavreus-Evers, AnneliUppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson(Swepub:uu)annst384 (author)
- Dept of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, USAInstitutionen för kvinnors och barns hälsa (creator_code:org_t)
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- In:Reproductive sciences (Thousand Oaks, Calif.): Springer Science and Business Media LLC17:9, s. 823-8321933-72051933-7191
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