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The GNAS1 T393C pol...
The GNAS1 T393C polymorphism and lack of clinical prognostic value in chronic lymphocytic leukemia
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- Kaderi, Mohd Arifin (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Murray, Fiona (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Jansson, Mattias (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Merup, Mats (author)
- Karolinska Institutet
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- Karlsson, Karin (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Roos, Göran (author)
- Umeå universitet,Patologi
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- Åleskog, Anna (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Tobin, Gerard (author)
- Uppsala universitet,Institutionen för genetik och patologi
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
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In: Leukemia Research. - : Elsevier BV. - 0145-2126 .- 1873-5835. ; 32:6, s. 984-987
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease with no known single predisposing genetic factor shown in all cases. Recently, a single nucleotide polymorphism (SNP) T393C in the GNAS1 gene has been reported to have a clinical impact on CLL progression and overall survival. In order to further investigate the T393C SNP in CLL, we have genotyped 279 CLL cases and correlated the genotypes to clinical outcome and other known prognostic factors such as the immunoglobulin heavy chain variable (IGHV) gene mutation status and CD38 expression. In the present study, no difference in overall survival or time to treatment was observed in the CLL patients with the different genotypes in contrast to the previous report. Furthermore, no correlation was observed with the T393C genotypes and IGHV mutational status, Binet stage or CD38 in this cohort. In summary, our data does not support the use of the T393C GNAS SNP as a clinical prognostic factor in CLL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- GNAS1 T393C single nucleotide polymorphism
- chronic lymphocytic leukemia prognosis
- MEDICINE
- MEDICIN
- leukemia prognosis
- GNAS1 T393C single nucleotide polymorphism
- chronic lymphocytic
Publication and Content Type
- ref (subject category)
- art (subject category)
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