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Amyloid β-protein, ...
Amyloid β-protein, Cystatin C and Cathepsin B as Biomarkers of Alzheimer's Disease
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- Sundelöf, Johan, 1974- (författare)
- Uppsala universitet,Geriatrik
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- Lannfelt, Lars, Professor (preses)
- Uppsala universitet,Geriatrik
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- Kilander, Lena, Docent (preses)
- Uppsala universitet,Geriatrik
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- Basun, Hans, Professor (preses)
- Uppsala universitet,Geriatrik
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- Sundstrom, Johan, Docent (preses)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Fratiglioni, Laura, Professor (opponent)
- Karolinska Institutet, Institutionen för neurobiologi, vårdvetenskap och samhälle (NVS)
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(creator_code:org_t)
- ISBN 9789155479565
- Uppsala : Acta Universitatis Upsaliensis, 2010
- Engelska 64 s.
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Serie: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1651-6206 ; 626
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- It is suggested that Alzheimer’s disease (AD) is caused by an imbalance between production, degradation and clearance of the amyloid-β (Aβ) protein. This imbalance leads to aggregation of Aβ and tau proteins and neurodegeneration in the brain. Today there is increasing evidence that the balance between the protease cathepsin B and the protease inhibitor cystatin C affects the tendency for Aβ to aggregate. The primary aim of this thesis was to investigate Aβ, cystatin C and cathepsin B levels in blood and cerebro-spinal fluid (CSF) in relation to the risk of AD.Studies I & II were based on the re-examinations of participants, at ages 70 and 77, in the Uppsala Longitudinal Study of Adult Men (ULSAM), a community-based prospective study initiated in 1970 (participants then being 50 years of age). In ULSAM, low plasma Aβ1-40 (Study I) and low serum cystatin C levels (Study II) were associated with a higher risk of AD. Studies III & IV were based on a cross-sectional sample of people with AD, mild cognitive impairment and healthy controls, recruited at three Swedish Memory Disorder units: Uppsala University Hospital, Uppsala, Skåne University Hospital, Malmö, and Karolinska University Hospital, Huddinge, Stockholm. In Study III, CSF cystatin C levels were positively correlated with both Aβ1-42 and tau levels. In Study IV, individuals with AD had higher mean plasma cathepsin B levels than healthy controls.In conclusion, low plasma Aβ1-40 and low serum cystatin C levels may precede clinically manifest AD in elderly men, cystatin C levels are positively correlated with Aβ1-42 and tau levels in CSF, and mean plasma cathepsin B levels are higher in people with AD compared to healthy controls. In addition to Aβ1-42 and tau levels in CSF, Aβ1-40, cystatin C and cathepsin B levels in blood may reflect the risk of AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- Alzheimer´s disease
- amyloid β-protein
- cystatin C
- cathepsin B
- biomarkers
- risk factors
- epidemiology
- Geriatrics and medical gerontology
- Geriatrik och medicinsk gerontologi
- Medicin
- Medicine
Publikations- och innehållstyp
- vet (ämneskategori)
- dok (ämneskategori)
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Sundelöf, Johan, ...
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Lannfelt, Lars, ...
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Kilander, Lena, ...
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Basun, Hans, Pro ...
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Sundstrom, Johan ...
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Fratiglioni, Lau ...
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