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  • Rubin, Johanna (author)

Use of intrathecal chemoprophylaxis in children after SCT and the risk of central nervous system relapse

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2010-05-24
  • Springer Science and Business Media LLC,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-130839
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-130839URI
  • https://doi.org/10.1038/bmt.2010.121DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:122134583URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Conflicting conclusions can be drawn from the available data concerning antileukemic efficacy and risks of intrathecal (i.t.) chemoprophylaxis to children after hematopoietic SCT (HSCT). To address this, we enrolled six transplantation centers with similar treatment and patient material. Of the 397 children included, 136 patients had received post-HSCT i.t. treatment (i.t. group) and 261 had not (non-i.t. group). The two groups were, apart from the i.t. therapy given or not given, at equal risk of post-HSCT central nervous system (CNS) relapse, which was the primary endpoint studied. Isolated CNS relapses were observed in 2 (1.5%) patients from the i.t. group and 2 (1%) from the non-i.t. group. Combined relapses, including CNS, involved 4 (3%) patients from the i.t. group and 6 (2%) from the non-i.t. group. Overall survival and the occurrence of neurological side effects did not differ significantly between the groups. There was no statistically significant difference in the incidence of isolated or mixed CNS relapses between the two groups, suggesting little or no benefit from i.t. therapy post-HSCT in children.

Subject headings and genre

  • Hematopoietic SCT
  • Intrathecal therapy
  • CNS relapses
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Vettenranta, K. (author)
  • Vettenranta, J. (author)
  • Bierings, M. (author)
  • Abrahamsson, J. (author)
  • Békássy, A. N. (author)
  • Håkansson, Y. (author)
  • Frost, Britt-MarieUppsala universitet,Pediatrik,Barnonkologisk forskning/Pfeifer(Swepub:uu)brittfo (author)
  • Arvidson, JohanUppsala universitet,Pediatrik,Barnonkologisk forskning/Pfeifer(Swepub:uu)johanas (author)
  • Spendilow, C. (author)
  • Winiarski, J.Karolinska Institutet (author)
  • Gustafsson, BrittKarolinska Institutet (author)
  • Uppsala universitetPediatrik (creator_code:org_t)

Related titles

  • In:Bone Marrow Transplantation: Springer Science and Business Media LLC46:3, s. 372-3780268-33691476-5365

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