Search: id:"swepub:oai:DiVA.org:uu-13084" >
Shb null allele is ...
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Kriz, VitezslavUppsala universitet,Institutionen för medicinsk cellbiologi
(author)
Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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2007
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Wiley,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-13084
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-13084URI
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https://doi.org/10.1002/dvdy.21257DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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SHB is an Src homology 2 domain-containing adapter protein that has been found to be involved in numerous cellular responses. We have generated an Shb knockout mouse. No Shb-/- pups or embryos were obtained on the C57Bl6 background, indicating an early defect as a consequence of Shb- gene inactivation on this genetic background. Breeding heterozygotes for Shb gene inactivation (Shb+/-) on a mixed genetic background (FVB/C57Bl6/129Sv) reveals a distorted transmission ratio of the null allele with reduced numbers of Shb+/+ and Shb-/- animals, but increased number of Shb+/- animals. The Shb- allele is associated with various forms of malformations, explaining the relative reduction in the number of Shb-/- offspring. Shb-/- animals that were born were viable, fertile, and showed no obvious defects. However, Shb+/- female mice ovulated preferentially Shb- oocytes explaining the reduced frequency of Shb+/+ mice. Our study suggests a role of SHB during reproduction and development.
Subject headings and genre
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Knockout
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Malformations
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Ovulation
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SHB
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Transmission ratio distortion
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Viability in utero
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Mares, Jaroslav
(author)
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Wentzel, ParriUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)parrwent
(author)
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Funa, Nina S.Uppsala universitet,Institutionen för medicinsk cellbiologi
(author)
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Calounova, GabrielaUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)gabca335
(author)
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Zhang, X-QUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)xiaozhan
(author)
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Forsberg-Nilsson, KarinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)karifors
(author)
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Forsberg, MaudUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)mafor226
(author)
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Welsh, MichaelUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)michwels
(author)
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Uppsala universitetInstitutionen för medicinsk cellbiologi
(creator_code:org_t)
Related titles
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In:Developmental Dynamics: Wiley236:9, s. 2485-24921058-83881097-0177
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