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Clinical and Experi...
Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle : Establishment of a Vascular System Similar to that in Native Islets
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- Christoffersson, Gustaf (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Henriksnäs, Johanna (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Johansson, Lars (författare)
- Uppsala universitet,Enheten för radiologi
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- Rolny, Charlotte (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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- Ahlström, Håkan (författare)
- Uppsala universitet,Enheten för radiologi
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- Caballero-Corbalán, José (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Segersvärd, Ralf (författare)
- Karolinska Institutet
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- Permert, Johan (författare)
- Karolinska Institutet
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- Korsgren, Olle (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Carlsson, Per-Ola (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för medicinska vetenskaper
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- Phillipson, Mia (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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(creator_code:org_t)
- 2010-07-22
- 2010
- Engelska.
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 59:10, s. 2569-2578
- Relaterad länk:
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http://diabetes.diab...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objective: Curing type 1 diabetes by transplanting pancreatic islets into the liver is associated with poor long-term outcome and graft failure at least partly due to inadequate graft revascularization. The aim of the current study was to evaluate striated muscle as a potential angiogenic site for islet transplantation. Research Design and Methods: The current study presents a new experimental model which is found applicable to clinical islet transplantation. Islets were implanted into striated muscle where after intra-islet vascular density and blood flow were visualized with intravital and confocal microscopy in mice, and by magnetic resonance imaging in three auto-transplanted pancreatectomized patients. Mice were rendered neutropenic by repeated injections of Gr-1 antibody and diabetes was induced by alloxan treatment. Results: Contrary to liver-engrafted islets, islets transplanted to mouse muscle were revascularized with vessel densities and blood flow entirely comparable to islets within intact pancreas. Initiation of islet revascularization at the muscular site was dependent on neutrophils, and the function of islets transplanted to muscle was proven by curing diabetic mice. The experimental data were confirmed in auto-transplanted patients where higher plasma volumes were measured in islets engrafted in forearm muscle compared to adjacent muscle tissue through high-resolution magnetic resonance imaging. Conclusions: This study presents a novel paradigm in islet transplantation whereby recruited neutrophils are crucial for the functionally restored intra-islet blood perfusion following transplantation to striated muscle under experimental and clinical situations.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Diabetes
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Christoffersson, ...
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Henriksnäs, Joha ...
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Johansson, Lars
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Rolny, Charlotte
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Ahlström, Håkan
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Caballero-Corbal ...
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visa fler...
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Segersvärd, Ralf
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Permert, Johan
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Korsgren, Olle
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Carlsson, Per-Ol ...
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Phillipson, Mia
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- Artiklar i publikationen
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Diabetes
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet