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Sox10 Has a Broad E...
Sox10 Has a Broad Expression Pattern in Gliomas and Enhances Platelet-Derived Growth Factor-B–Induced Gliomagenesis
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- Ferletta, Maria (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Uhrbom, Lene (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Olofsson, Tommie (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Pontén, Fredrik (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Westermark, Bengt (author)
- Uppsala universitet,Institutionen för genetik och patologi
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: Molecular Cancer Research. - 1541-7786 .- 1557-3125. ; 5:9, s. 891-897
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In a previously published insertional mutagenesis screen for candidate brain tumor genes in the mouse using a Moloney mouse leukemia virus encoding platelet-derived growth factor (PDGF)-B, the Sox10 gene was tagged in five independent tumors. The proviral integrations suggest an enhancer effect on Sox10. All Moloney murine leukemia virus/PDGFB tumors had a high protein expression of Sox10 independently of malignant grade or tumor type. To investigate the role of Sox10 in gliomagenesis, we used the RCAS/tv-a mouse model in which the expression of retroviral-encoded genes can be directed to glial progenitor cells (Ntv-a mice). Both Ntv-a transgenic mice, wild-type, and Ntv-a p19Arf null mice were injected with RCAS-SOX10 alone or in combination with RCAS-PDGFB. Infection with RCAS-SOX10 alone did not induce any gliomas. Combined infection of RCAS-SOX10 and RCAS-PDGFB in wild-type Ntv-a mice yielded a tumor frequency of 12%, and in Ntv-a Arf−/− mice the tumor frequency was 30%. This indicates that Sox10 alone is not sufficient to induce gliomagenesis but acts synergistically with PDGFB in glioma development. All induced tumors displayed characteristics of PNET-like structures and oligodendroglioma. The tumors had a strong and widely distributed expression of Sox10 and PDGFR-α. We investigated the expression of Sox10 in other human tumors and in a number of gliomas. The Sox10 expression was restricted to gliomas and melanomas. All glioma types expressed Sox10, and tumors of low-grade glioma had a much broader distribution of Sox10 compared with high-grade gliomas.
Keyword
- Animals
- Astrocytoma/genetics
- Brain Neoplasms/*genetics/pathology
- Chickens
- DNA-Binding Proteins/*genetics
- Gene Expression Regulation; Neoplastic
- Glioblastoma/genetics
- Glioma/*genetics/*pathology
- High Mobility Group Proteins/*genetics
- Humans
- Intermediate Filament Proteins/genetics
- Melanoma/genetics
- Mice
- Nerve Tissue Proteins/genetics
- Platelet-Derived Growth Factor/*physiology
- Promoter Regions (Genetics)
- Transcription Factors/*genetics
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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