Systemic and local eosinophil inflammation during the birch pollen season in allergic patients with predominant rhinitis or asthma

Sökning: L773:1476 7961 > Systemic and local ...

Kämpe, Mary,1956-Uppsala universitet,Lungmedicin och allergologi,lungmedicine and allergology (författare)

BackgroundThe aim of the study was to investigate inflammation during the birch pollen season in patients with rhinitis or asthma.MethodsSubjects with birch pollen asthma (n = 7) or rhinitis (n = 9) and controls (n = 5) were studied before and during pollen seasons. Eosinophils (Eos), eosinophil cationic protein (ECP) and human neutrophil lipocalin were analysed.ResultsAllergic asthmatics had a larger decline in FEV1 after inhaling hypertonic saline than patients with rhinitis (median) (-7.0 vs.-0.4%, p = 0.02). The asthmatics had a lower sesonal PEFR than the rhinitis group. The seasonal increase in B-Eos was higher among patients with asthma (+0.17 × 109/L) and rhinitis (+0.27 × 109/L) than among controls (+0.01 × 109/L, p = 0.01). Allergic asthmatics and patients with rhinitis had a larger increase in sputum ECP (+2180 and +310 μg/L) than the controls (-146 μg/L, p = 0.02). No significant differences in inflammatory parameters were found between the two groups of allergic patients.ConclusionPatients with allergic asthma and rhinitis have the same degree of eosinophil inflammation. Despite this, only the asthmatic group experienced an impairment in lung function during the pollen season.

Stålenheim, GunnemarUppsala universitet,Lungmedicin och allergologi(Swepub:uu)gunnstal (författare)
Janson, ChristerUppsala universitet,Lungmedicin och allergologi(Swepub:uu)chrisjn (författare)
Stolt, IngridUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)ingrstol (författare)
Carlson, MarieUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)maricarl (författare)
Uppsala universitetLungmedicin och allergologi (creator_code:org_t)

Av författaren/redakt...: Kämpe, Mary, 195 ...; Stålenheim, Gunn ...; Janson, Christer; Stolt, Ingrid; Carlson, Marie

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

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