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CIN85 regulates dop...
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
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- Shimokawa, Noriaki (author)
- Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
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- Haglund, Kaisa (author)
- Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
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- Hölter, Sabine M (author)
- Institute of Developmental Genetics, Helmholtz Zentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg, Germany
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- Grabbe, Caroline (author)
- Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
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- Kirkin, Vladimir (author)
- Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
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- Koibuchi, Noriyuki (author)
- Department of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma, Japan
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- Schultz, Christian (author)
- Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Goethe University, Frankfurt (Main), Germany
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- Rozman, Jan (author)
- Molecular Nutritional Medicine, Else-Kroner-Fresenius Center, Technische Universitat Munchen, Freising-Weihenstephan, Germany
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- Hoeller, Daniela (author)
- Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
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- Qiu, Chun-Hong (author)
- Department of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma, Japan
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- Londoño, Marina B (author)
- Department of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma, Japan
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- Ikezawa, Jun (author)
- Department of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma, Japan
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- Jedlicka, Peter (author)
- Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Goethe University, Frankfurt (Main), Germany
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- Stein, Birgit (author)
- Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
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- Schwarzacher, Stephan W (author)
- Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Goethe University, Frankfurt (Main), Germany,Institute of Developmental Genetics, Helmholtz Zentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg, Germany
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- Wolfer, David P (author)
- Institute of Anatomy, University of Zurich, and Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland
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- Ehrhardt, Nicole (author)
- Molecular Nutritional Medicine, Else-Kroner-Fresenius Center, Technische Universitat Munchen, Freising-Weihenstephan, Germany
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- Heuchel, Rainer (author)
- Karolinska Institutet,Uppsala universitet,Ludwiginstitutet för cancerforskning
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- Nezis, Ioannis (author)
- Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
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- Brech, Andreas (author)
- Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
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- Schmidt, Mirko H H (author)
- Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
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- Fuchs, Helmut (author)
- Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany
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- Gailus-Durner, Valerie (author)
- Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany
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- Klingenspor, Martin (author)
- Molecular Nutritional Medicine, Else-Kroner-Fresenius Center, Technische Universitat Munchen, Freising-Weihenstephan, Germany
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- Bogler, Oliver (author)
- Departments of Neurosurgery, Neuro-Oncology and Brain Tumor Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA
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- Wurst, Wolfgang (author)
- Institute of Developmental Genetics, Helmholtz Zentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg, Germany
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- Deller, Thomas (author)
- Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Goethe University, Frankfurt (Main), Germany
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- de Angelis, Martin Hrabé (author)
- Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany
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- Dikic, Ivan (author)
- Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
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(creator_code:org_t)
- 2010-06-15
- 2010
- English.
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In: EMBO Journal. - : European Molecular Biology Organization. - 0261-4189 .- 1460-2075. ; 29:14, s. 2421-2432
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Despite extensive investigations of Cbl-interacting protein of 85 kDa (CIN85) in receptor trafficking and cytoskeletal dynamics, little is known about its functions in vivo. Here, we report the study of a mouse deficient of the two CIN85 isoforms expressed in the central nervous system, exposing a function of CIN85 in dopamine receptor endocytosis. Mice lacking CIN85 exon 2 (CIN85(Deltaex2)) show hyperactivity phenotypes, characterized by increased physical activity and exploratory behaviour. Interestingly, CIN85(Deltaex2) animals display abnormally high levels of dopamine and D2 dopamine receptors (D2DRs) in the striatum, an important centre for the coordination of animal behaviour. Importantly, CIN85 localizes to the post-synaptic compartment of striatal neurons in which it co-clusters with D2DRs. Moreover, it interacts with endocytic regulators such as dynamin and endophilins in the striatum. Absence of striatal CIN85 causes insufficient complex formation of endophilins with D2DRs in the striatum and ultimately decreased D2DR endocytosis in striatal neurons in response to dopamine stimulation. These findings indicate an important function of CIN85 in the regulation of dopamine receptor functions and provide a molecular explanation for the hyperactive behaviour of CIN85(Deltaex2) mice.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- CIN85
- dopamine receptor
- endocytosis hyperactivity
- synapse
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Shimokawa, Noria ...
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Haglund, Kaisa
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Hölter, Sabine M
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Grabbe, Caroline
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Kirkin, Vladimir
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Koibuchi, Noriyu ...
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show more...
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Schultz, Christi ...
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Rozman, Jan
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Hoeller, Daniela
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Qiu, Chun-Hong
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Londoño, Marina ...
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Ikezawa, Jun
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Jedlicka, Peter
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Stein, Birgit
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Schwarzacher, St ...
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Wolfer, David P
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Ehrhardt, Nicole
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Heuchel, Rainer
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Nezis, Ioannis
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Brech, Andreas
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Schmidt, Mirko H ...
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Fuchs, Helmut
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Gailus-Durner, V ...
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Klingenspor, Mar ...
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Bogler, Oliver
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Wurst, Wolfgang
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Deller, Thomas
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de Angelis, Mart ...
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Dikic, Ivan
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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EMBO Journal
- By the university
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Uppsala University
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Umeå University
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Karolinska Institutet