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Ca(2+)-induced Ca2+...
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Islam, M. ShahidulUppsala universitet,Medicin
(författare)
Ca(2+)-induced Ca2+ release in insulin-secreting cells
- Artikel/kapitelEngelska1992
Förlag, utgivningsår, omfång ...
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2002-01-16
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Wiley,1992
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-132306
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132306URI
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https://doi.org/10.1016/0014-5793(92)80306-2DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The sulphydryl reagent thimerosal (50 microM) released Ca2+ from a non-mitochondrial intracellular Ca2+ pool in a dose-dependent manner in permeabilized insulin-secreting RINm5F cells. This release was reversed after addition of the reducing agent dithiothreitol. Ca2+ was released from an Ins(1,4,5)P3-insensitive pool, since release was observed even after depletion of the Ins(1,4,5)P3-sensitive pool by a supramaximal dose of Ins(2,4,5)P3 or thapsigargin. The Ins(1,4,5)P3-sensitive pool remained essentially unaltered by thimerosal. Thimerosal-induced Ca2+ release was potentiated by caffeine. These findings suggest the existence of Ca(2+)-induced Ca2+ release also in insulin-secreting cells.
Ämnesord och genrebeteckningar
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Ca2+-induced Ca2+ release
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Sulphydryl reagent
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Thimerosal
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Intracellular Ca2+ transport
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Insulin-secreting cell
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Permeabilized cell
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rorsman, Patrik
(författare)
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Berggren, Per-Olof
(författare)
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Uppsala universitetMedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:FEBS Letters: Wiley296:3, s. 287-2910014-57931873-3468
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