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  • Sugano, Kiyohiko (author)

Coexistence of passive and carrier-mediated processes in drug transport

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • Springer Science and Business Media LLC,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-132385
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132385URI
  • https://doi.org/10.1038/nrd3187DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The permeability of biological membranes is one of the most important determinants of the pharmacokinetic processes of a drug. Although it is often accepted that many drug substances are transported across biological membranes by passive transcellular diffusion, a recent hypothesis speculated that carrier-mediated mechanisms might account for the majority of membrane drug transport processes in biological systems. Based on evidence of the physicochemical characteristics and of in vitro and in vivo findings for marketed drugs, as well as results from real-life discovery and development projects, we present the view that both passive transcellular processes and carrier-mediated processes coexist and contribute to drug transport activities across biological membranes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kansy, Manfred (author)
  • Artursson, PerUppsala universitet,Institutionen för farmaci(Swepub:uu)perartur (author)
  • Avdeef, Alex (author)
  • Bendels, Stefanie (author)
  • Di, Li (author)
  • Ecker, Gerhard F (author)
  • Faller, Bernard (author)
  • Fischer, Holger (author)
  • Gerebtzoff, Grégori (author)
  • Lennernäs, HansUppsala universitet,Institutionen för farmaci(Swepub:uu)hanslenn (author)
  • Senner, Frank (author)
  • Uppsala universitetInstitutionen för farmaci (creator_code:org_t)

Related titles

  • In:Nature reviews. Drug discovery: Springer Science and Business Media LLC9:8, s. 597-6141474-17761474-1784

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