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Serum cathepsin S i...
Serum cathepsin S is associated with serum C-reactive protein and interleukin-6 independently of obesity in elderly men
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- Jobs, Elisabeth (författare)
- Högskolan Dalarna,Uppsala universitet,Geriatrik,Medicinsk vetenskap,Uppsala university
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- Risérus, Ulf (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Ingelsson, Erik (författare)
- Karolinska Institutet,Uppsala universitet,Geriatrik
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- Helmersson, Johanna (författare)
- Uppsala universitet,Oxidativ stress och inflammation
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- Nerpin, Elisabet (författare)
- Högskolan Dalarna,Uppsala universitet,Geriatrik,Medicinsk vetenskap
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- Jobs, Magnus (författare)
- Högskolan Dalarna,Medicinsk vetenskap
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- Sundström, Johan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Larsson, Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Basu, Samar (författare)
- Uppsala universitet,Oxidativ stress och inflammation
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- Ärnlöv, Johan (författare)
- Högskolan Dalarna,Uppsala universitet,Geriatrik,Medicinsk vetenskap
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(creator_code:org_t)
- The Endocrine Society, 2010
- 2010
- Engelska.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 95:9, s. 4460-4464
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
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- OBJECTIVE: Cathepsin S has been suggested provide a mechanistic link between obesity and atherosclerosis, possibly mediated via adipose tissue-derived inflammation. Previous data have shown an association between circulating cathepsin S and inflammatory markers in the obese, but to date, community-based reports are lacking. Accordingly, we aimed to investigate the association between serum levels of cathepsin S and markers of cytokine-mediated inflammation in a community-based sample, with prespecified subgroup analyses in nonobese participants. METHODS: Serum cathepsin S, C-reactive protein (CRP), and IL-6 were measured in a community-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men; mean age 71 years, n = 991). CRP and IL-6 were also measured at a reexamination after 7 yr. RESULTS: After adjustment for age, body mass index, fasting plasma glucose, diabetes treatment, systolic blood pressure, diastolic blood pressure, hypertension treatment, serum cholesterol, serum high-density lipoprotein cholesterol, prior cardiovascular disease, smoking, and leisure time physical activity, higher cathepsin S was associated with higher CRP (regression coefficient for 1 sd increase, 0.13; 95% confidence interval 0.07-0.19; P < 0.001) and higher serum IL-6 (regression coefficient for 1 sd increase, 0.08; 95% confidence interval 0.01-0.14; P = 0.02). These associations remained similar in normal-weight participants (body mass index <25 kg/m(2), n = 375). In longitudinal analyses, higher cathepsin S at baseline was associated with higher serum CRP and IL-6 after 7 yr. CONCLUSIONS: These results provide additional evidence for the interplay between cathepsin S and inflammatory activity and suggest that this association is present also in normal-weight individuals in the community.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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- MEDICINE
- MEDICIN
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- Av författaren/redakt...
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Jobs, Elisabeth
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Risérus, Ulf
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Ingelsson, Erik
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Helmersson, Joha ...
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Nerpin, Elisabet
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Jobs, Magnus
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visa fler...
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Sundström, Johan
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Lind, Lars
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Larsson, Anders
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Basu, Samar
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Ärnlöv, Johan
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visa färre...
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Uppsala universitet
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Högskolan Dalarna
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Karolinska Institutet