A multidimensional analysis of genes mutated in breast and colorectal cancers

• A recent study of a large number of genes in a panel of breast and colorectal cancers identified somatic mutations in 1149 genes. To identify potential biological processes affected by these genes, we examined their putative roles based on sequence similarity, membership in known functional groups and pathways, and predicted interactions with other proteins. These analyses identified functional groups and pathways that were enriched for mutated genes in both tumor types. Additionally, the results pointed to differences in molecular mechanisms that underlie breast and colorectal cancers, including various intracellular signaling and metabolic pathways. These studies provide a multidimensional framework to guide further research and help identify cellular processes critical for malignant progression and therapeutic intervention.

Nyckelord

Amino Acid Sequence

Breast Neoplasms/classification/*genetics/metabolism

Cluster Analysis

Colorectal Neoplasms/classification/*genetics/metabolism

Female

Gene Expression Regulation

Neoplastic

Genes

Neoplasm

Humans

Models

Biological

Molecular Sequence Data

Mutation

Neoplasm Proteins/chemistry/genetics/metabolism

Protein Structure

Tertiary

Sequence Homology

Amino Acid

MEDICINE

MEDICIN

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)