Brachial artery hyperemic blood flow velocity and left ventricular geometry

• ABSTRACT OBJECTIVE Cardiovascular risk factors and carotid atherosclerosis relates to blood flow velocity in the brachial artery during induced hyperemia. This relation proved to be particularly strong when using the hyperemic systolic to diastolic blood flow velocity (SDFV) ratio. In this study, we further investigated this ratios value as a marker of vascular risk in relation to left ventricular (LV) geometry. MATERIAL AND METHODS In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, 1016 70-year-olds participated. Blood flow velocity during hyperemia of the brachial artery by Doppler was analysed. Echocardiography was performed, allowing analysis of LV geometry, categorised into four different groups: normal, concentric remodeling, concentric- and eccentric- hypertrophy. RESULTS                                                                                                                                     The SDFV ratio was increased in subjects with concentric LV -remodeling (p=0.006) or -hypertrophy (p=0.001), but not in those with eccentric hypertrophy (p=0.12) when compared to the group with normal LV geometry. These associations remained significant after adjustment for gender, blood pressure, blood glucose, body mass index and antihypertensive treatment. CONCLUSION The hyperemic systolic to diastolic blood flow velocity ratio in the brachial artery was related to concentric geometry of the LV in an elderly population sample, suggesting this new hemodynamic variable as a marker of increased afterload.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

brachial blood flow velocity left ventricular geometry

Cardiovascular medicine

Kardiovaskulär medicin

Medical Science

Medicinsk vetenskap

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