The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study

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Lambert, Jean-Charles (author)

The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease : a Meta-Analysis Study

Article/chapterEnglish2010

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2010
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LIBRIS-ID:oai:DiVA.org:uu-133613
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-133613URI
https://doi.org/10.3233/JAD-2010-100933DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the epsilon 4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the epsilon 4 allele of the APOE gene.

Subject headings and genre

Age at onset
Alzheimer's disease
apolipoprotein E
CALHM1
polymorphism
MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Sleegers, Kristel (author)
Gonzalez-Perez, Antonio (author)
Ingelsson, MartinUppsala universitet,Geriatrik,Molekylär geriatrik(Swepub:uu)maing121 (author)
Beecham, Gary W. (author)
Hiltunen, Mikko (author)
Combarros, Onofre (author)
Bullido, Maria J. (author)
Brouwers, Nathalie (author)
Bettens, Karolien (author)
Berr, Claudine (author)
Pasquier, Florence (author)
Richard, Florence (author)
DeKosky, Steven T. (author)
Hannequin, Didier (author)
Haines, Jonathan L. (author)
Tognoni, Gloria (author)
Fievet, Nathalie (author)
Dartigues, Jean-Francois (author)
Tzourio, Christophe (author)
Engelborghs, Sebastiaan (author)
Arosio, Beatrice (author)
Coto, Elicer (author)
De Deyn, Peter (author)
Del Zompo, Maria (author)
Mateo, Ignacio (author)
Boada, Merce (author)
Antunez, Carmen (author)
Lopez-Arrieta, Jesus (author)
Epelbaum, Jacques (author)
Schjcide, Brit-Marcn Michaud (author)
Frank-Garcia, Ana (author)
Giedraitis, VilmantasUppsala universitet,Geriatrik,Molekylär geriatrik(Swepub:uu)vigie517 (author)
Helisalmi, Seppo (author)
Porcellini, Elisa (author)
Pilotto, Alberto (author)
Forti, Paola (author)
Ferri, Raffaele (author)
Delepine, Marc (author)
Zelenika, Diana (author)
Lathrop, Mark (author)
Scarpini, Elio (author)
Siciliano, Gabriele (author)
Solfrizzi, Vincenzo (author)
Sorbi, Sandro (author)
Spalletta, Gianfranco (author)
Ravaglia, Giovanni (author)
Valdivieso, Fernando (author)
Vepsäläinen, SailaUniversity of Eastern Finland, Institute of Clinical Medicine / Neurology (author)
Alvarez, Victoria (author)
Bosco, Paolo (author)
Mancuso, Michelangelo (author)
Panza, Francesco (author)
Nacmias, Benedetta (author)
Bossu, Paola (author)
Hanon, Olivier (author)
Piccardi, Paola (author)
Annoni, Giorgio (author)
Mann, David (author)
Marambaud, Philippe (author)
Seripa, Davide (author)
Galimberti, Daniela (author)
Tanzi, Rudolph E. (author)
Bertram, Lars (author)
Lendon, Corinne (author)
Lannfelt, LarsUppsala universitet,Geriatrik,Molekylär geriatrik(Swepub:uu)lalan021 (author)
Licastro, Federico (author)
Campion, Dominique (author)
Pericak-Vance, Margaret A. (author)
Soininen, Hilkka (author)
Van Broeckhoven, Christine (author)
Alperovitch, Annick (author)
Ruiz, Agustin (author)
Kamboh, M. Ilyas (author)
Amouyel, Philippe (author)
Uppsala universitetGeriatrik (creator_code:org_t)

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In:Journal of Alzheimer's Disease22:1, s. 247-2551387-28771875-8908

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By the author/editor: Lambert, Jean-Ch ...; Sleegers, Kriste ...; Gonzalez-Perez, ...; Ingelsson, Marti ...; Beecham, Gary W.; Hiltunen, Mikko; show more...; Combarros, Onofr ...; Bullido, Maria J ...; Brouwers, Nathal ...; Bettens, Karolie ...; Berr, Claudine; Pasquier, Floren ...; Richard, Florenc ...; DeKosky, Steven ...; Hannequin, Didie ...; Haines, Jonathan ...; Tognoni, Gloria; Fievet, Nathalie; Dartigues, Jean- ...; Tzourio, Christo ...; Engelborghs, Seb ...; Arosio, Beatrice; Coto, Elicer; De Deyn, Peter; Del Zompo, Maria; Mateo, Ignacio; Boada, Merce; Antunez, Carmen; Lopez-Arrieta, J ...; Epelbaum, Jacque ...; Schjcide, Brit-M ...; Frank-Garcia, An ...; Giedraitis, Vilm ...; Helisalmi, Seppo; Porcellini, Elis ...; Pilotto, Alberto; Forti, Paola; Ferri, Raffaele; Delepine, Marc; Zelenika, Diana; Lathrop, Mark; Scarpini, Elio; Siciliano, Gabri ...; Solfrizzi, Vince ...; Sorbi, Sandro; Spalletta, Gianf ...; Ravaglia, Giovan ...; Valdivieso, Fern ...; Vepsäläinen, Sai ...; Alvarez, Victori ...; Bosco, Paolo; Mancuso, Michela ...; Panza, Francesco; Nacmias, Benedet ...; Bossu, Paola; Hanon, Olivier; Piccardi, Paola; Annoni, Giorgio; Mann, David; Marambaud, Phili ...; Seripa, Davide; Galimberti, Dani ...; Tanzi, Rudolph E ...; Bertram, Lars; Lendon, Corinne; Lannfelt, Lars; Licastro, Federi ...; Campion, Dominiq ...; Pericak-Vance, M ...; Soininen, Hilkka; Van Broeckhoven, ...; Alperovitch, Ann ...; Ruiz, Agustin; Kamboh, M. Ilyas; Amouyel, Philipp ...; show less...

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