Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes

Epstein-Barr virus (EBV) is a human gamma herpes virus that infects B cells and induces their transformation into immortalized lymphoblasts that can grow as cell lines (LCLs) in vitro. EBNA-3 is a member of the EBNA-3-protein family that can regulate transcription of cellular and viral genes. The identification of EBNA-3 cellular partners and a study of its influence on cellular pathways are important for understanding the transforming action of the virus. In this work, we have identified the vitamin D receptor (VDR) protein as a binding partner of EBNA-3. We found that EBNA3 blocks the activation of VDR-dependent genes and protects LCLs against vitamin-D3-induced growth arrest and/or apoptosis. The presented data shed some light on the anti-apoptotic EBV program and the role of the EBNA-3-VDR interaction in the viral strategy.

Hellman, UlfUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)ulfhm (author)
Kempkes, Bettina (author)
Darekar, Suhas DeoramKarolinska Institutet (author)
Petermann, Sabine (author)
Sculley, Tom (author)
Klein, GeorgeKarolinska Institutet (author)
Kashuba, ElenaKarolinska Institutet (author)
Uppsala universitetLudwiginstitutet för cancerforskning (creator_code:org_t)

In:Cellular and Molecular Life Sciences (CMLS): Springer Science and Business Media LLC67:24, s. 4249-42561420-682X1420-9071

By the author/editor: Yenamandra, Sury ...; Hellman, Ulf; Kempkes, Bettina; Darekar, Suhas D ...; Petermann, Sabin ...; Sculley, Tom; show more...; Klein, George; Kashuba, Elena; show less...

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