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Association analyse...
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Speliotes, Elizabeth K.
(author)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-10-10
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Springer Science and Business Media LLC,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-134102
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134102URI
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https://doi.org/10.1038/ng.686DOI
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https://lup.lub.lu.se/record/1718942URI
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https://gup.ub.gu.se/publication/127911URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121530056URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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De sju sista författarna delar sistaförfattarskapet.
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Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
Subject headings and genre
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Willer, Cristen J.
(author)
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Berndt, Sonja I.
(author)
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Monda, Keri L.
(author)
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Thorleifsson, Gudmar
(author)
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Jackson, Anne U.
(author)
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Allen, Hana Lango
(author)
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Lindgren, Cecilia M.
(author)
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Luan, Jian'an
(author)
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Maegi, Reedik
(author)
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Randall, Joshua C.
(author)
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Vedantam, Sailaja
(author)
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Winkler, Thomas W.
(author)
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Qi, Lu
(author)
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Workalemahu, Tsegaselassie
(author)
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Heid, Iris M.
(author)
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Steinthorsdottir, Valgerdur
(author)
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Stringham, Heather M.
(author)
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Weedon, Michael N.
(author)
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Wheeler, Eleanor
(author)
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Wood, Andrew R.
(author)
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Ferreira, Teresa
(author)
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Weyant, Robert J.
(author)
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Segre, Ayellet V.
(author)
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Estrada, Karol
(author)
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Liang, Liming
(author)
-
Nemesh, James
(author)
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Park, Ju-Hyun
(author)
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Gustafsson, Stefan
(author)
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Kilpelaenen, Tuomas O.
(author)
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Yang, Jian
(author)
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Bouatia-Naji, Nabila
(author)
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Esko, Tonu
(author)
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Feitosa, Mary F.
(author)
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Kutalik, Zoltan
(author)
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Mangino, Massimo
(author)
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Raychaudhuri, Soumya
(author)
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Scherag, Andre
(author)
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Smith, Albert Vernon
(author)
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Welch, Ryan
(author)
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Zhao, Jing Hua
(author)
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Aben, Katja K.
(author)
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Absher, Devin M.
(author)
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Amin, Najaf
(author)
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Dixon, Anna L.
(author)
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Fisher, Eva
(author)
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Glazer, Nicole L.
(author)
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Goddard, Michael E.
(author)
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Heard-Costa, Nancy L.
(author)
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Hoesel, Volker
(author)
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Hottenga, Jouke-Jan
(author)
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Johansson, ÅsaUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)asjoh108
(author)
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Johnson, Toby
(author)
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Ketkar, Shamika
(author)
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Lamina, Claudia
(author)
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Li, Shengxu
(author)
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Moffatt, Miriam F.
(author)
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Myers, Richard H.
(author)
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Narisu, Narisu
(author)
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Perry, John R. B.
(author)
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Peters, Marjolein J.
(author)
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Preuss, Michael
(author)
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Ripatti, Samuli
(author)
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Rivadeneira, Fernando
(author)
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Sandholt, Camilla
(author)
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Scott, Laura J.
(author)
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Timpson, Nicholas J.
(author)
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Tyrer, Jonathan P.
(author)
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van Wingerden, Sophie
(author)
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Watanabe, Richard M.
(author)
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White, Charles C.
(author)
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Wiklund, FredrikKarolinska Institutet
(author)
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Barlassina, Christina
(author)
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Chasman, Daniel I.
(author)
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Cooper, Matthew N.
(author)
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Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xjanjo
(author)
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Lawrence, Robert W.
(author)
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Pellikka, Niina
(author)
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Prokopenko, Inga
(author)
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Shi, Jianxin
(author)
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Thiering, Elisabeth
(author)
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Alavere, Helene
(author)
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Alibrandi, Maria T. S.
(author)
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Almgren, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-pal
(author)
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Arnold, Alice M.
(author)
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Aspelund, Thor
(author)
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Atwood, Larry D.
(author)
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Balkau, Beverley
(author)
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Balmforth, Anthony J.
(author)
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Bennett, Amanda J.
(author)
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Ben-Shlomo, Yoav
(author)
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Bergman, Richard N.
(author)
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Bergmann, Sven
(author)
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Biebermann, Heike
(author)
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Blakemore, Alexandra I. F.
(author)
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Boes, Tanja
(author)
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Bonnycastle, Lori L.
(author)
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Bornstein, Stefan R.
(author)
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Brown, Morris J.
(author)
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Buchanan, Thomas A.
(author)
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Busonero, Fabio
(author)
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Campbell, Harry
(author)
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Cappuccio, Francesco P.
(author)
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Cavalcanti-Proenca, Christine
(author)
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Chen, Yii-Der Ida
(author)
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Chen, Chih-Mei
(author)
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Chines, Peter S.
(author)
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Clarke, Robert
(author)
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Coin, Lachlan
(author)
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Connell, John
(author)
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Day, Ian N. M.
(author)
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den Heijer, Martin
(author)
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Duan, Jubao
(author)
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Ebrahim, Shah
(author)
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Elliott, Paul
(author)
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Elosua, Roberto
(author)
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Eiriksdottir, Gudny
(author)
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Erdos, Michael R.
(author)
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Eriksson, Johan G.
(author)
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Facheris, Maurizio F.
(author)
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Felix, Stephan B.
(author)
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Fischer-Posovszky, Pamela
(author)
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Folsom, Aaron R.
(author)
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Friedrich, Nele
(author)
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Freimer, Nelson B.
(author)
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Fu, Mao
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Gaget, Stefan
(author)
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Gejman, Pablo V.
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Geus, Eco J. C.
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Gieger, Christian
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Gjesing, Anette P.
(author)
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Goel, Anuj
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Goyette, Philippe
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Grallert, Harald
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Graessler, Juergen
(author)
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Greenawalt, Danielle M.
(author)
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Groves, Christopher J.
(author)
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Gudnason, Vilmundur
(author)
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Guiducci, Candace
(author)
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Hartikainen, Anna-Liisa
(author)
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Hassanali, Neelam
(author)
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Hall, Alistair S.
(author)
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Havulinna, Aki S.
(author)
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Hayward, Caroline
(author)
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Heath, Andrew C.
(author)
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Hengstenberg, Christian
(author)
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Hicks, Andrew A.
(author)
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Hinney, Anke
(author)
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Hofman, Albert
(author)
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Homuth, Georg
(author)
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Hui, Jennie
(author)
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Igl, WilmarUppsala universitet,Institutionen för genetik och patologi
(author)
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Iribarren, Carlos
(author)
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Isomaa, Bo
(author)
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Jacobs, Kevin B.
(author)
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Jarick, Ivonne
(author)
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Jewell, Elizabeth
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John, Ulrich
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Jorgensen, Torben
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Jousilahti, Pekka
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Jula, Antti
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Kaakinen, Marika
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Kajantie, Eero
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Kaplan, Lee M.
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Kathiresan, Sekar
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Kettunen, Johannes
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Kinnunen, Leena
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Knowles, Joshua W.
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Kolcic, Ivana
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Koenig, Inke R.
(author)
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Koskinen, Seppo
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Kovacs, Peter
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Kuusisto, Johanna
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Kraft, Peter
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Lantieri, Olivier
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Lanzani, Chiara
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Lecoeur, Cecile
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Lehtimaeki, Terho
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Lettre, Guillaume
(author)
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Liu, Jianjun
(author)
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Lokki, Marja-Liisa
(author)
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Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xlomat
(author)
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Luben, Robert N.
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Ludwig, Barbara
(author)
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Manunta, Paolo
(author)
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Marek, Diana
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Marre, Michel
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McArdle, Wendy L.
(author)
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McCarthy, Anne
(author)
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McKnight, Barbara
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Meitinger, Thomas
(author)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
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Meyre, David
(author)
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Midthjell, Kristian
(author)
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Montgomery, Grant W.
(author)
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Morken, Mario A.
(author)
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Morris, Andrew P.
(author)
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Mulic, Rosanda
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Ngwa, Julius S.
(author)
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Nelis, Mari
(author)
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Neville, Matt J.
(author)
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Nyholt, Dale R.
(author)
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O'Donnell, Christopher J.
(author)
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O'Rahilly, Stephen
(author)
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Ong, Ken K.
(author)
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Oostra, Ben
(author)
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Pare, Guillaume
(author)
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Parker, Alex N.
(author)
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Perola, Markus
(author)
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Pichler, Irene
(author)
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Pietilaeinen, Kirsi H.Karolinska Institutet
(author)
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Platou, Carl G. P.
(author)
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Polasek, Ozren
(author)
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Pouta, Anneli
(author)
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Rafelt, Suzanne
(author)
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Raitakari, Olli
(author)
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Rayner, Nigel W.
(author)
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Ridderstråle, MartinLund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups(Swepub:lu)endo-mri
(author)
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Rief, Winfried
(author)
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Ruokonen, Aimo
(author)
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Robertson, Neil R.
(author)
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Rzehak, Peter
(author)
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Salomaa, Veikko
(author)
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Sanders, Alan R.
(author)
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Sandhu, Manjinder S.
(author)
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Sanna, Serena
(author)
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Saramies, Jouko
(author)
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Savolainen, Markku J.
(author)
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Scherag, Susann
(author)
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Schipf, Sabine
(author)
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Schreiber, Stefan
(author)
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Schunkert, Heribert
(author)
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Silander, Kaisa
(author)
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Sinisalo, Juha
(author)
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Siscovick, David S.
(author)
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Smit, Jan H.
(author)
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Soranzo, Nicole
(author)
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Sovio, Ulla
(author)
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Stephens, Jonathan
(author)
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Surakka, Ida
(author)
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Swift, Amy J.
(author)
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Tammesoo, Mari-Liis
(author)
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Tardif, Jean-Claude
(author)
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Teder-Laving, Maris
(author)
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Teslovich, Tanya M.
(author)
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Thompson, John R.
(author)
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Thomson, Brian
(author)
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Toenjes, Anke
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Tuomi, Tiinamaija
(author)
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van Meurs, Joyce B. J.
(author)
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van Ommen, Gert-Jan
(author)
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Vatin, Vincent
(author)
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Viikari, Jorma
(author)
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Visvikis-Siest, Sophie
(author)
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Vitart, Veronique
(author)
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Vogel, Carla I. G.
(author)
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Voight, Benjamin F.
(author)
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Waite, Lindsay L.
(author)
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Wallaschofski, Henri
(author)
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Walters, G. Bragi
(author)
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Widen, Elisabeth
(author)
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Wiegand, Susanna
(author)
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Wild, Sarah H.
(author)
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Willemsen, Gonneke
(author)
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Witte, Daniel R.
(author)
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Witteman, Jacqueline C.
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Xu, Jianfeng
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Zhang, Qunyuan
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Zgaga, Lina
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Ziegler, Andreas
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Zitting, Paavo
(author)
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Beilby, John P.
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Farooqi, I. Sadaf
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Hebebrand, Johannes
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Huikuri, Heikki V.
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James, Alan L.
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Kaehoenen, Mika
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Levinson, Douglas F.
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Macciardi, Fabio
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Nieminen, Markku S.
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xohlcl
(author)
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Palmer, Lyle J.
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Ridker, Paul M.
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Stumvoll, Michael
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Caulfield, Mark J.
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Smith, George Davey
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Erdmann, Jeanette
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Froguel, Philippe
(author)
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Greonberg, HenrikKarolinska Institutet
(author)
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Gyllensten, UlfUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)ulfgyll
(author)
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Hall, Per
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Hansen, Torben
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Harris, Tamara B.
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Hattersley, Andrew T.
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Kaprio, Jaakko
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Karpe, Fredrik
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Khaw, Kay-Tee
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Kiemeney, Lambertus A.
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Krude, Heiko
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Laakso, Markku
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Lawlor, Debbie A.
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Munroe, Patricia B.
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Ouwehand, Willem H.
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Pedersen, Oluf
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Penninx, Brenda W.
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Peters, Annette
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Pramstaller, Peter P.
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Quertermous, Thomas
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Reinehr, Thomas
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Rissanen, Aila
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Rudan, Igor
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Samani, Nilesh J.
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Schwarz, Peter E. H.
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Shuldiner, Alan R.
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Spector, Timothy D.
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Tuomilehto, Jaakko
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Fox, Caroline S.
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
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Haritunians, Talin
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Hunter, David J.
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Kaplan, Robert C.
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Mohlke, Karen L.
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O'Connell, Jeffrey R.
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Peltonen, Leena
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van Duijn, Cornelia M.
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Frayling, Timothy M.
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Thorsteinsdottir, Unnur
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Abecasis, Goncalo R.
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Barroso, Ines
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Boehnke, Michael
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Stefansson, Kari
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North, Kari E.
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McCarthy, Mark I.
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Hirschhorn, Joel N.
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Ingelsson, ErikKarolinska Institutet
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Gräßler, Jürgen
(author)
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Uppsala universitetInstitutionen för genetik och patologi
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In:Nature Genetics: Springer Science and Business Media LLC42:11, s. 937-9481061-40361546-1718
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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and Health Sciences
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- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Lund University
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University of Gothenburg
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Karolinska Institutet