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Melphalan and predn...
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Waage, AndersDepartment of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway,NTNU
(författare)
Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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American Society of Hematology,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-135021
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-135021URI
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https://doi.org/10.1182/blood-2009-08-237974DOI
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https://lup.lub.lu.se/record/1697871URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-36855URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-59727URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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In this double-blind, placebo-controlled study, 363 patients with untreated multiple myeloma were randomized to receive either melphalan-prednisone and thalidomide (MPT) or melphalan-prednisone and placebo (MP). The dose of melphalan was 0.25 mg/kg and prednisone was 100 mg given daily for 4 days every 6 weeks until plateau phase. The dose of thalidomide/placebo was escalated to 400 mg daily until plateau phase and thereafter reduced to 200 mg daily until progression. A total of 357 patients were analyzed. Partial response was 34% and 33%, and very good partial response or better was 23% and 7% in the MPT and MP arms, respectively (P < .001). There was no significant difference in progression-free or overall survival, with median survival being 29 months in the MPT arm and 32 months in the MP arm. Most quality of life outcomes improved equally in both arms, apart from constipation, which was markedly increased in the MPT arm. Constipation, neuropathy, non-neuropathy neurologic toxicity, and skin reactions were significantly more frequent in the MPT arm. The number of thromboembolic events was equal in the 2 treatment arms. In conclusion, MPT had a significant antimyeloma effect, but this did not translate into improved survival. This trial was registered at www.clinicaltrials.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gimsing, PeterDepartment of Hematology, Rigshospitalet and University of Copenhagen
(författare)
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Fayers, PeterDepartment of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
(författare)
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Abildgaard, NielsDepartment of Hematology, Odense University Hospital, Odense, Denmark
(författare)
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Ahlberg, LuciaÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Hematologiska kliniken US(Swepub:liu)lucah64
(författare)
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Björkstrand, BoHematology Centre, Karolinska University Hospital/Huddinge, Stockholm, Sweden
(författare)
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Carlson, KristinaUppsala universitet,Medicin,Hematologi,Department of Hematology, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)krica965
(författare)
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Forsberg, KarinUmeå universitet,Onkologi,Norrland University Hospital(Swepub:umu)nonkin02
(författare)
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Dahl, Inger MarieDepartment of Medicine, University Hospital Tromsø, Tromsø, Norway
(författare)
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Gulbrandsen, NinaDepartment of Hematology, Ullevål University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway
(författare)
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Haukas, EinarDepartment of Medicine, Stavanger University Hospital, Stavanger, Norway
(författare)
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Hjertner, ÖyvindDepartment of Hematology, St Olavs Hospital and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
(författare)
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Hjorth, MartinDepartment of Hematology, Lidköping Hospital, Lidköping, Sweden
(författare)
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Karlsson, TorbjörnUppsala universitet,Medicin,Hematologi,Department of Internal Medicine, Capio Sankt Görans Hospital, Stockholm, Sweden(Swepub:uu)tokar839
(författare)
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Knudsen, Lene MeldgaardDepartment of Hematology, Herlev Hospital, Copenhagen, Denmark
(författare)
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Nielsen, Johan LanngDepartment of Hematology, Aarhus University Hospital, Aarhus, Denmark
(författare)
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Linder, OlleDepartment of Medicine, Örebro University Hospital, Örebro, Sweden
(författare)
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Mellqvist, Ulf-HenrikDepartment of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
(författare)
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Nesthus, IngeridDepartment of Medicine, Haukeland University Hospital, Bergen, Norway
(författare)
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Rolke, JurgenDepartment of Medicine, Kristiansand Hospital, Kristiansand, Norway
(författare)
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Strandberg, MariaDepartment of Medicine, Sundsvalls Hospital, Sundsvall, Sweden
(författare)
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Sörbo, Jon HjalmarDepartment of Medicine, Levanger Hospital, Levanger, Norway
(författare)
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Wislöff, FinnDepartment of Hematology, Ullevål University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway
(författare)
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Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Lund University Hospital, Lund, Sweden(Swepub:lu)stem-gju
(författare)
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Turesson, IngemarLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Medicine, Malmö University Hospital, Malmö, Sweden(Swepub:lu)medf-itu
(författare)
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Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, NorwayNTNU
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Blood: American Society of Hematology116:9, s. 1405-14120006-49711528-0020
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Waage, Anders
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Gimsing, Peter
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Fayers, Peter
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Abildgaard, Niel ...
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Ahlberg, Lucia
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Björkstrand, Bo
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visa fler...
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Carlson, Kristin ...
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Forsberg, Karin
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Dahl, Inger Mari ...
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Gulbrandsen, Nin ...
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Haukas, Einar
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Hjertner, Öyvind
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Hjorth, Martin
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Karlsson, Torbjö ...
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Knudsen, Lene Me ...
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Nielsen, Johan L ...
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Linder, Olle
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Mellqvist, Ulf-H ...
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Nesthus, Ingerid
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Rolke, Jurgen
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Strandberg, Mari ...
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Sörbo, Jon Hjalm ...
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Wislöff, Finn
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Juliusson, Gunna ...
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Turesson, Ingema ...
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