Motor unit number index (MUNIX): principle, method, and findings in healthy subjects and in patients with motor neuron disease

Motor unit number index (MUNIX) : principle, method, and findings in healthy subjects and in patients with motor neuron disease

The motor unit number index (MUNIX) is a method for assessment of number and size (MUSIX) of motor units (MUs) using the compound muscle action potential (CMAP) and surface electromyographic interference pattern (SIP). This method was used to study the hypothenar muscle in 34 healthy subjects to define normal range, and to study reproducibility. Four healthy subjects and 13 patients with amyotrophic lateral sclerosis (ALS) were studied serially over a 1-year period. In healthy subjects, MUNIX showed good reproducibility. In serial studies, healthy subjects showed no change in the CMAP amplitude and MUNIX. ALS patients with minimal change in CMAP amplitude had a significant drop in MUNIX and increase in MUSIX, indicating MU loss compensated by reinnervation. When the CMAP changed significantly (>30%) in 1 year, the CMAP and MUNIX decreased in parallel. MUNIX would be useful to study MU loss in degenerative diseases of motor neurons.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
motor neuron disease
motor unit
motor unit number estimation (MUNE)
serial studies
surface EMG
Clinical neurophysiology
Klinisk neurofysiologi

Barkhaus, Paul E. (author)
Stålberg, Erik V.Uppsala universitet,Klinisk neurofysiologi(Swepub:uu)eriksb (author)
Uppsala universitetKlinisk neurofysiologi (creator_code:org_t)

By the author/editor: Nandedkar, Sanje ...; Barkhaus, Paul E ...; Stålberg, Erik V ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.